22 March 2022: Clinical Research
Causes of Lower Respiratory Tract Infections and the Use of Diagnostic Biomarkers in Blood Samples from Children in Hohhot, Inner Mongolia, China, Between July 2019 and June 2020
Yanzi Gan 1ABCDEFG , YuWei Hu 1BC , Hairong Dong 1CD , Lina Wu 1DE , Yan Niu 12AEF*DOI: 10.12659/MSM.934889
Med Sci Monit 2022; 28:e934889
Table 5 The receiver operating characteristic curve values of white blood cells, procalcitonin, and C-reactive protein for groups with indicated pathogens and the healthy group. Diagonal segments are produced by ties.
| Clinical indicators | Pathogens | Cutoff | AUC | Sensitivity | Specificity |
|---|---|---|---|---|---|
| WBC | Bacterial | 9.73 | 0.69 | 48.30% | 96.80% |
| Virus | 7.12 | 0.63 | 60.70% | 76.20% | |
| Mycoplasma | 7.02 | 0.51 | 50.00% | 71.00% | |
| Bacterial infection & virus | 15.08 | 0.59 | 27.60% | 96.40% | |
| Bacterial infection & mycoplasma | 9.18 | 0.74 | 51.70% | 90.00% | |
| Virus infection & mycoplasma | 7.90 | 0.70 | 87.30% | 57.10% | |
| CRP | Bacterial | 5.02 | 0.74 | 69.00% | 100.00% |
| Virus | 4.38 | 0.51 | 39.30% | 95.20% | |
| Mycoplasma | 4.31 | 0.66 | 60.00% | 93.50% | |
| Bacterial infection & virus | 4.92 | 0.7 | 69.00% | 67.90% | |
| Bacterial infection & mycoplasma | 6.59 | 0.73 | 65.50% | 100.00% | |
| Virus infection & mycoplasma | – | 0.43 | – | – | |
| PCT | Bacterial | 0.03 | 0.89 | 89.70% | 93.50% |
| Virus | 0.03 | 0.80 | 78.60% | 90.50% | |
| Mycoplasma | 0.03 | 0.80 | 80.00% | 93.50% | |
| Bacterial infection & virus | 0.11 | 0.65 | 41.40% | 89.10% | |
| Bacterial infection & mycoplasma | 0.07 | 0.70 | 65.50% | 70.00% | |
| Virus infection & mycoplasma | 0.15 | 0.54 | 17.90% | 100.00% | |
| ROC – receiver operating characteristic curve; WBC – white blood cells; PCT – procalcitonin; CRP – C-reactive protein; AUC – area under the curve. | |||||