02 December 2021 : Clinical Research
Copy Number Variation Analysis of IL22 and LCE3C in Different Subtypes of Psoriasis in a Chinese Han Population
Caihong Zhu
1234ABCDEF, Wenmin Fei14BDF, Wenjun Wang123CD, Lili Tang123BC, Jinping Gao1234CF, Fusheng Zhou1234ACDEFG*
DOI: 10.12659/MSM.934927
Med Sci Monit 2021; 27:e934927
Table 1 Demographic and clinical data of study participants.
| Phenotypes1 | Severity | No. | Age | Gender | |||
|---|---|---|---|---|---|---|---|
| Average (range)2 | P3 | Male | Female | P4 | |||
| Healthy controls | 419 | 35.7 (4–84) | / | 268 (63.9%) | 151 (36.0%) | / | |
| All patients | 478 | 39.6 (6–90) | <0.001 | 280 (58.6%) | 198 (41.4%) | 0.11 | |
| PsV | 283 | 36.9 (7–78) | 0.16 | 161 (56.8%) | 122 (43.1%) | 0.07 | |
| Mild | 45 | 40.6 (13–76) | / | 29 (64.44%) | 16 (35.56%) | / | |
| Moderate | 203 | 36.2 (7–78) | 0.07() | 114 (56.16%) | 89 (43.84%) | <0.001() | |
| Severe | 35 | 36.2 (13–58) | 0.184() | 18 (51.43%) | 17 (48.57%) | 0.001() | |
| PsA | 74 | 45.1 (14–90) | <0.001 | 46 (62.2%) | 28 (37.8%) | 0.86 | |
| GPP | 52 | 31.4 (6–71) | 0.09 | 24 (46.2%) | 28 (53.8%) | 0.02 | |
| EP | 69 | 51.0 (11–85) | <0.001 | 49 (83.1%) | 20 (33.8%) | 0.32 | |
| 1 Clinical phenotypes of controls and psoriasis patients. PsV – psoriasis vulgaris; PsA – psoriatic arthritis; GPP – generalized pustular psoriasis; EP – erythrodermic psoriasis. 2 Age (in years) values are given as the mean and range (minimum–maximum). 3 Mann-Whitney test (each subgroup of patients versus controls). 4 Pearson’s chi-square test (each subgroup of patients versus controls). 5 Mann-Whitney test (each subgroup of patients versus Mild group). 6 Pearson’s chi-square test (each subgroup of patients in the Mild group). | |||||||