Copy Number Variation Analysis of IL22 and LCE3C in Different Subtypes of Psoriasis in a Chinese Han Population

02 December 2021: Clinical Research

Caihong Zhu ^1234ABCDEF , Wenmin Fei ^14BDF , Wenjun Wang ^123CD , Lili Tang ^123BC , Jinping Gao ^1234CF , Fusheng Zhou ^1234ACDEFG*

DOI: 10.12659/MSM.934927

Med Sci Monit 2021; 27:e934927

Table 1 Demographic and clinical data of study participants.

Phenotypes1	Severity	No.	Age		Gender
Phenotypes1	Severity	No.	Average (range)2	P3	Male	Female	P4
Healthy controls		419	35.7 (4–84)	/	268 (63.9%)	151 (36.0%)	/
All patients		478	39.6 (6–90)		280 (58.6%)	198 (41.4%)	0.11
PsV		283	36.9 (7–78)	0.16	161 (56.8%)	122 (43.1%)	0.07
	Mild	45	40.6 (13–76)	/	29 (64.44%)	16 (35.56%)	/
	Moderate	203	36.2 (7–78)	0.07()	114 (56.16%)	89 (43.84%)
	Severe	35	36.2 (13–58)	0.184()	18 (51.43%)	17 (48.57%)	0.001()
PsA		74	45.1 (14–90)		46 (62.2%)	28 (37.8%)	0.86
GPP		52	31.4 (6–71)	0.09	24 (46.2%)	28 (53.8%)	0.02
EP		69	51.0 (11–85)		49 (83.1%)	20 (33.8%)	0.32
¹ Clinical phenotypes of controls and psoriasis patients. PsV – psoriasis vulgaris; PsA – psoriatic arthritis; GPP – generalized pustular psoriasis; EP – erythrodermic psoriasis. ² Age (in years) values are given as the mean and range (minimum–maximum). ³ Mann-Whitney test (each subgroup of patients versus controls). ⁴ Pearson’s chi-square test (each subgroup of patients versus controls). ⁵ Mann-Whitney test (each subgroup of patients versus Mild group). ⁶ Pearson’s chi-square test (each subgroup of patients in the Mild group).