16 March 2022>: Clinical Research
Effect of Cerebral Microbleeds on Cognitive Function and Quality of Life in Parkinson Disease
Qixiong Qin 1ABCDEF , Hengming Wan 2C , Danlei Wang 1B , Jingyi Li 1B , Qingmei Yang 1B , Jingwei Zhao 1B , Zheng Xue 1ADFGDOI: 10.12659/MSM.935026
Med Sci Monit 2022; 28:e935026
Table 4 The associations of cerebral microbleeds (CMBs) with cognition and quality of life in Parkinson disease.
The presence of CMBs | |||
---|---|---|---|
R2 | β | p-value | |
MMSE total score | 0.140 | 0.301 | |
MoCA total score | 0.104 | 0.289 | |
Visuospatial abilities | 0.139 | −0.165 | 0.027 |
Naming | 0.098 | −0.197 | 0.010 |
Attention | 0.173 | −0.298 | |
Language | 0.040 | 0.037 | 0.629 |
Abstraction | 0.053 | −0.003 | 0.971 |
Delayed memory | 0.099 | −0.128 | 0.094 |
Orientation | 0.080 | −0.151 | 0.050 |
PDQ-39 SI | 0.113 | 0.108 | 0.166 |
Mobility SI | 0.114 | 0.103 | 0.188 |
Activity of daily living SI | 0.078 | 0.112 | 0.159 |
Emotional well-beings SI | 0.033 | 0.024 | 0.765 |
Stigma SI | 0.007 | 0.033 | 0.684 |
Social support SI | 0.020 | −0.065 | 0.426 |
Cognition SI | 0.093 | 0.074 | 0.346 |
Communication SI | 0.082 | 0.022 | 0.785 |
Bodily discomfort SI | 0.066 | −0.045 | 0.568 |
Adjusted values are listed in the table. The association of CMBs with MMSE and MoCA was adjusted for sex, age, education levels, disease duration, and LEDD. The association of CMBs with QoL was adjusted for sex, age, education levels, disease duration, LEDD, UPDRS-III, and MMSE or MoCA. # Compared with CMB-free group, the difference was statistically significant. CMBs – cerebral microbleeds; MMSE – Mini Mental State Examination; MoCA – Montreal Cognitive Assessment; QoL – quality of life; PDQ-39 – 39-item Parkinson disease questionnaire; SI – summary index. |