A Review of the Impact of Neutrophils and Neutrophil Extracellular Traps (NETs) on the Development of Aortic Aneurysms in Animal and Human Studies

Milena Michalska; Tadeusz Grochowiecki; Tomasz Jakimowicz; Sławomir Nazarewski

doi:10.12659/MSM.935134

28 December 2021 : Review article

A Review of the Impact of Neutrophils and Neutrophil Extracellular Traps (NETs) on the Development of Aortic Aneurysms in Animal and Human Studies

Milena Michalska

^1ABCDEFG*, Tadeusz Grochowiecki^1AEFG, Tomasz Jakimowicz

^1DEF, Sławomir Nazarewski^1D

DOI: 10.12659/MSM.935134

Med Sci Monit 2021; 27:e935134

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Background Use of Animal Models in AA Pathogenesis of Aortic Aneurysm and Neutrophilic Role Inflammation Atherosclerosis and Thrombosis NETosis in Vascular Pathologies Process of Visualization and Measurement of NETs NETs in AAA NETs in Other Diseases that Can Be Risk Factors of AAA Conclusions References

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Table 1 Comparison of animal models of aortic aneurysm.

Model	Severity	Rupture	Dissection
Angiotensin II perfusion [,]¹⁰	Moderate	Yes	Yes
Elastase perfusion [,]¹⁰	Moderate	No	No
Calcium chloride or phosphate usage [,]¹⁰	Mild	No	No
Xenograft []⁵	Severe	Yes	Yes

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A Review of the Impact of Neutrophils and Neutrophil Extracellular Traps (NETs) on the Development of Aortic Aneurysms in Animal and Human Studies

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