28 December 2021: Review Articles
A Review of the Impact of Neutrophils and Neutrophil Extracellular Traps (NETs) on the Development of Aortic Aneurysms in Animal and Human Studies
Milena Michalska ABCDEFG* , Tadeusz Grochowiecki AEFG , Tomasz Jakimowicz DEF , Sławomir Nazarewski DDOI: 10.12659/MSM.935134
Med Sci Monit 2021; 27:e935134
Background
Use of Animal Models in AA
Pathogenesis of Aortic Aneurysm and Neutrophilic Role
Inflammation
Atherosclerosis and Thrombosis
NETosis in Vascular Pathologies
Process of Visualization and Measurement of NETs
NETs in AAA
NETs in Other Diseases that Can Be Risk Factors of AAA
Conclusions
References
Table 1 Comparison of animal models of aortic aneurysm.
| Model | Advantages | Limitations | Severity | Mechanism | Rupture | Dissection | Positive risk factors of AAA in humans |
|---|---|---|---|---|---|---|---|
| Angiotensin II perfusion [,]10 | Moderate | Yes | Yes | ||||
| Elastase perfusion [,]10 | Moderate | No | No | ||||
| Calcium chloride or phosphate usage [,]10 | Mild | No | No | ||||
| Xenograft []5 | Severe | Yes | Yes |