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23 May 2022: Clinical Research

Microalbuminuria Complicated with Low Estimated Glomerular Filtration Rate: Early Risk Factors for Contrast-Induced Acute Kidney Injury After Coronary Intervention

Meijuan Hu 12ABCDEF , Erfei Luo 2E , Gaoliang Yan 3D , Chengchun Tang 3BCE , Lei Wang 1BCF , Qigao Zhang 1ABE , Jianbin Gong 1AE*

DOI: 10.12659/MSM.935455

Med Sci Monit 2022; 28:e935455

Table 1 Baseline clinical characteristics.

Clinical variablesMA group (n=222)NA group (n=721)P value
Age (years)74.5±8.775.3±7.90.157
Male sex, n (%)166 (74.8)571 (79.2)0.163
Body mass index (kg/m)24.2±2.324.1±2.30.682
Smoker98 (44.1)362 (50.2)0.114
Underlying disease
 Diabetes148 (66.7)177 (24.5)
 Heart failure24 (10.6)63 (8.8)0.351
 Hypertension160 (72.1)510 (70.7)0.701
 Hyperlipidemia65 (29.3)169 (23.4)0.078
 Myocardial infarction23 (10.4)66 (9.2)0.591
Vital signs
 SBP (mmHg)132.9±15.3134.0±14.40.335
 DBP (mmHg)79.1±8.580.3±8.90.062
 ACEI/ARB125 (56.3)389 (54.0)0.538
 Statin206 (92.8)663 (92.0)0.685
 Calcium antagonist65 (29.3)234 (32.5)0.374
 Diuretic31 (14.0)97 (13.5)0.846
 β-blocker167 (75.2)525 (72.8)0.477
 Isosorbide dinitrate184 (82.9)599 (83.1)0.946
 Aspirin220 (99.1)711 (98.6)0.572
 Clopidogrel198 (89.2)663 (92.0)0.201
Baseline laboratory data
 Serum creatinine (μmol/L)136.3±69.5130.9±60.10.265
 eGFR (mL/min/1.73 m)55.3±32.556.6±31.40.581
 ACR (mg/g)93.5±53.911.8±6.2
 Blood urea nitrogen (mmol/L)6.4±2.66.3±2.20.328
 Uric acid (μmol/L)372.9±75.6369.8±76.30.594
 Fasting blood glucose (mmol/L)6.7±1.25.5±1.3
 Cystatin C (mg/L)1.2±0.31.2±0.80.266
 NGAL (ng/mL)9.4±9.310.2±9.40.301
 Contrast volume, mL125.8±68.5126.5±65.10.891
 Contrast volume/eGFR2.9±1.92.8±1.70.414
 PCI, n (%)109 (49.1)311 (43.1)0.118
ACEI – angiotensin converting enzyme inhibitor; ACR – albuminuria urine creatinine ratio; ARB – angiotensin receptor blocker; CRP – C-reactive protein; DBP – diastolic blood pressure; eGFR – estimate glomerular filtration rate; MA – microalbuminuria; NA – normal-albuminuria; NGAL – Neutrophil gelatinase-related apolipoprotein; PCI – percutaneous coronary intervention; SBP – systolic blood pressure. Data are expressed as number (%) or mean±standard deviation.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750