External Quality Assessment of Maternal Serum Levels of Alpha-Fetoprotein, Free Beta-Human Chorionic Gonadotropin, and Unconjugated Estriol in Detecting Down Syndrome and Neural Tube Defects in the Second Trimester of 87 Maternal Serum Samples, Based on 105-139 Days

13 April 2022 : Clinical Research

Yiming Chen

^12AEG*, Yijie Chen

^2BE, Yezhen Shi^3CD, Wenwen Ning^2BE, Xiaoying Wang^1B, Liyao Li^1BC, Huimin Zhang^2F

DOI: 10.12659/MSM.935573

Med Sci Monit 2022; 28:e935573

Background Material and Methods Results Discussion Conclusions References

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Table 2 Correlation analysis of screening results between 5 screening laboratories and Laboratory A.

Laboratory/screening indicators	R value	The regression equation	P value	R2
Lab B
AFP MoM	0.996	Y=−0.016+0.966X	<0.001	0.993
free β-hCG MoM	0.994	Y=0.080+0.951X	<0.001	0.988
uE3 MoM	0.973	Y=0.078+0.915X	<0.001	0.946
Lab C
AFP MoM	0.994	Y=−0.016+0.966X	<0.001	0.987
free β-hCG MoM	0.994	Y=0.080+0.951X	<0.001	0.988
uE3 MoM	0.966	Y=0.078+0.915X	<0.001	0.932
Lab D
AFP MoM	0.995	Y=−0.064+1.020X	<0.001	0.992
free β-hCG MoM	0.992	Y=−0.065+1.080X	<0.001	0.994
uE3 MoM	0.967	Y=0.138+0.877X	<0.001	0.935
Lab E
AFP MoM	0.999	Y=0.010+0.916X	<0.001	0.998
free β-hCG MoM	0.998	Y=−0.016+0.929X	<0.001	0.996
uE3 MoM	0.978	Y=0.008+1.000X	<0.001	0.957
Lab F
AFP MoM	0.981	Y=−0.136+0.824X	<0.001	0.962
free β-hCG MoM	0.993	Y=−0.015+0.879X	<0.001	0.986
uE3 MoM	0.913	Y=0.019+0.920X	<0.001	0.834
Lab – laboratory; AFP – α-fetoprotein; free β-hCG – free beta human chorionic gonadotropin; uE3 – unconjugated estriol; MoM – multiple of median.

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