External Quality Assessment of Maternal Serum Levels of Alpha-Fetoprotein, Free Beta-Human Chorionic Gonadotropin, and Unconjugated Estriol in Detecting Down Syndrome and Neural Tube Defects in the Second Trimester of 87 Maternal Serum Samples, Based on 105-139 Days

13 April 2022 : Clinical Research

Yiming Chen

^12AEG*, Yijie Chen

^2BE, Yezhen Shi^3CD, Wenwen Ning^2BE, Xiaoying Wang^1B, Liyao Li^1BC, Huimin Zhang^2F

DOI: 10.12659/MSM.935573

Med Sci Monit 2022; 28:e935573

Background Material and Methods Results Discussion Conclusions References

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Table 6 Comparison of neural tube defect screening effect in 6 different laboratories.

Lab	Low/High risk	NTD diagnostic result		Total	P value	Kappa value
Lab	Low/High risk	Normal	NTD	Total	P value	Kappa value
Lab A	Low risk	78	2	80	0.500	0.738
Lab A	High risk	0	3	3	0.500	0.738
Lab B	Low risk	78	2	80	0.500	0.738
Lab B	High risk	0	3	3	0.500	0.738
Lab C	Low risk	78	4	82	0.125	0.320
Lab C	High risk	0	1	1	0.125	0.320
Lab D	Low risk	78	2	80	0.500	0.738
Lab D	High risk	0	3	3	0.500	0.738
Lab E	Low risk	78	2	80	0.500	0.738
Lab E	High risk	0	3	3	0.500	0.738
Lab F	Low risk	78	4	82	0.125	0.320
Lab F	High risk	0	1	1	0.125	0.320
Lab – laboratory; NTD – neural tube defects; PR – positive rate; DR – detection rate.

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