External Quality Assessment of Maternal Serum Levels of Alpha-Fetoprotein, Free Beta-Human Chorionic Gonadotropin, and Unconjugated Estriol in Detecting Down Syndrome and Neural Tube Defects in the Second Trimester of 87 Maternal Serum Samples, Based on 105-139 Days

Yiming Chen; Yijie Chen; Yezhen Shi; Wenwen Ning; Xiaoying Wang; Liyao Li; Huimin Zhang

doi:10.12659/MSM.935573

13 April 2022 : Clinical Research

External Quality Assessment of Maternal Serum Levels of Alpha-Fetoprotein, Free Beta-Human Chorionic Gonadotropin, and Unconjugated Estriol in Detecting Down Syndrome and Neural Tube Defects in the Second Trimester of 87 Maternal Serum Samples, Based on 105-139 Days

Yiming Chen

^12AEG*, Yijie Chen

^2BE, Yezhen Shi^3CD, Wenwen Ning^2BE, Xiaoying Wang^1B, Liyao Li^1BC, Huimin Zhang^2F

DOI: 10.12659/MSM.935573

Med Sci Monit 2022; 28:e935573

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Supplementary Table 2 Correlation analysis of free beta human chorionic gonadotropin (free β-hCG) multiple of the median (MoM) value in 6 laboratories.

Laboratory		Lab A	Lab B	Lab C	Lab D	Lab E	Lab F
Lab A		1	0.994^**	0.994^**	0.992^**	0.998^**	0.993^**

	N	87	87	87	87	87	87
Lab B		0.994^**	1	0.990^**	0.987^**	0.995^**	0.993^**

	N	87	87	87	87	87	87
Lab C		0.994^**	0.990^**	1	0.996^**	0.994^**	0.992^**

	N	87	87	87	87	87	87
Lab D		0.992^**	0.987^**	0.996^**	1	0.993^**	0.988^**

	N	87	87	87	87	87	87
Lab E		0.998^**	0.995^**	0.994^**	0.993^**	1	0.995^**

	N	87	87	87	87	87	87
Lab F		0.993^**	0.993^**	0.992^**	0.988^**	0.995^**	1

	N	87	87	87	87	87	87
^** Correlation is significant at a 0.01 level (2-tailed).

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External Quality Assessment of Maternal Serum Levels of Alpha-Fetoprotein, Free Beta-Human Chorionic Gonadotropin, and Unconjugated Estriol in Detecting Down Syndrome and Neural Tube Defects in the Second Trimester of 87 Maternal Serum Samples, Based on 105-139 Days

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