22 March 2022 : Clinical Research
Comparison of the Effectiveness of Endometrial Receptivity Analysis (ERA) to Guide Personalized Embryo Transfer with Conventional Frozen Embryo Transfer in 281 Chinese Women with Recurrent Implantation Failure
Yan Jia1BCDEF, Yulin Sha12BF, Zhu Qiu1BCD, Yanhua Guo1CE, Aixiang Tan1EF, Yan Huang1EF, Ying Zhong1EF, Yajun Dong1ADF, Hongxia Ye1ADG*DOI: 10.12659/MSM.935634
Med Sci Monit 2022; 28:e935634
Table 2 Comparison of the clinical outcomes between transfer of day 5 and day 6 embryos in the endometrial receptivity analysis (ERA) and conventional frozen embryo transfer (FET) groups.
| Clinical outcome | ERA group (n=140) | FET group (n=141) | ||||
|---|---|---|---|---|---|---|
| Transfer of day-5 embryos | Transfer of day-6 embryos | P value | Transfer of day-5 embryos | Transfer of day-6 embryos | P value | |
| Biochemical pregnancy rate, (%) | 56/89 (62.92%) | 32/51 (62.75%) | >0.05 | 36/88 (40.91%) | 19/53 (35.85%) | >0.05 |
| Clinical pregnancy rate, (%) | 47/89 (52.81%) | 23/51 (45.1) | >0.05 | 19/88 (21.59%) | 16/53 (30.19%) | >0.05 |
| Implantation rate, (%) | 64/141 (45.39% | 27/77 (35.06% | >0.05 | 23/139 (16.55%) | 19/84 (22.62) | >0.05 |
| Clinical miscarriage rate, (%) | 4/56 (7.14%) | 5/32 (15.63%) | >0.05 | 6/36 (16.67%) | 3/19 (15.79%) | >0.05 |
| Biochemical miscarriage rate, (%) | 9/56 (16.07%) | 9/32 (28.13%) | >0.05 | 16/36 (44.44%) | 2/19 (10.53%) | <0.05 |
| Ectopic pregnancy rate, (%) | 0/56 (0) | 0/32 (0) | >0.05 | 0/36 (0) | 0/19 (0) | >0.05 |
| Embryos transferred per patient, | 1.58±0.32 | 1.51±0.45 | >0.05 | 1.58±0.54 | 1.58±0.47 | >0.05 |
| High-quality embryos transferred per patient, | 0.72±0.43 | 0.78±0.27 | >0.05 | 1.07±0.35 | 0.92±0.22 | >0.05 |
| Cumulative biochemical pregnancy rate, (%) | 62/88 (70.45%) | 37/52 (71.15%) | >0.05 | 40/79 (50.63%) | 28/62 (45.16) | >0.05 |
| Cumulative clinical pregnancy rate, (%) | 50/88 (56.82%) | 30/52 (57.69%) | >0.05 | 31/79 (39.24%) | 26/62 (41.94%) | >0.05 |
| Cumulative implantation rate, (%) | 67/141 (47.52%) | 35/76 (46.05%) | >0.05 | 39/129 (30.23%) | 29/99 (29.29%) | >0.05 |
| Cumulative clinical miscarriage rate, (%) | 4/62 (6.45%) | 6/37 (16.22%) | >0.05 | 4/40 (10%) | 4/28 (14.29%) | >0.05 |
| Cumulative biochemical miscarriage rate, (%) | 11/62 (17.74%) | 7/37 (18.92%) | >0.05 | 8/40 (20%) | 1/28 (3.57%) | >0.05 |
| Cumulative ectopic pregnancy rate, (%) | 0/62 (0) | 0/37 (0) | >0.05 | 0/40 (0) | 0/28 (0) | >0.05 |
| Cumulative embryos transferred per patient, | 1.6±0.39 | 1.46±0.41 | >0.05 | 1.53±0.41 | 1.58±0.39 | >0.05 |
| Cumulative high-quality embryos transferred per patient, | 0.77±0.29 | 0.71±0.3 | >0.05 | 0.940.11± | 0.89±0.21 | >0.05 |