23 March 2022 : Clinical Research
Intravenous Lidocaine for Postoperative Analgesia in 90 patients After Total Knee Arthroplasty and Limb Fractures
Rajmonda Nallbani
1ABCDEFG*, Edmond Komoni2ABCDEF, Fatos Sada1ABCDEF, Ismet Q. Jusufi3ABCDEF, Antigona Hasani 1ABCDEF
DOI: 10.12659/MSM.935852
Med Sci Monit 2022; 28:e935852
Table 3 Logistic regression analysis of VAS in patients treated with lidocaine and controls. Controls had significantly higher VAS scores after 30 min, even after adjusting for age, sex, BMI, time of surgery, anesthesia, and risk factors (hypertension, diabetes, smoking).
| VAS at rest | OR | (95% CI) | P-value | VAS during movement | OR | (95% CI) | P-value |
|---|---|---|---|---|---|---|---|
| 0 min | 0.179 | (−0.39 to 0.78) | P=0.51 | 0 min | 2.25 | (0.95 to 3.54) | P=0.07 |
| 15 min | 0.39 | (−0.22 to 0.96) | P=0.203 | 15 min | 1.64 | (1.1 to 2.35) | P=0.006 |
| 30 min | 2.62 | (1.75 to 3.51) | P=0.007 | 30 min | 2.4 | (1.5 to 3.2) | P<0.001 |
| 1 h | 9.54 | (6.59 to 12.50) | P<0.001 | 1 h | 3.7 | (1.8 to 5.6) | P<0.001 |
| 6 h | 3.66 | (1.69 to 5.64) | P<0.001 | 6 h | 9.8 | (6.9 to 12.8) | P<0.001 |
| 12 h | 4.36 | (1.53 to 4.36) | P<0.001 | 12 h | 2.5 | (1.3 to 3.6) | P<0.001 |
| 24 h | 3.71 | (1.70 to 5.72) | P<0.001 | 24 h | 3.6 | (1.6 to 5.6) | P<0.001 |
| Data are expressed as odds ratios and 95% confidence intervals. VAS – visual analog scale; BMI – body mass index. | |||||||