25 June 2022 : Clinical Research
Serum TP53 Protein Level as a Sensitive Biomarker for the Diagnosis of Myocardial Damage in Children
Xianglin Zeng1EF, Chunwang Lin1AEG*, Yanna Sun1BD, Jianping Zhang1CFDOI: 10.12659/MSM.936248
Med Sci Monit 2022; 28:e936248
Table 1 Characteristics of the patient population at admission.
| All patients | Myocardial damage | Non-myocardial damage | P | |
|---|---|---|---|---|
| Number of subjects | 100 | 50 | 50 | – |
| Age, y | 7.86±1.6 | 8.23±3.12 | 8.05±1.4 | 0.26 |
| Male % | 53.7 | 56.0 | 51.4 | 0.74 |
| Heart rate, beats/min | 110±26 | 126±28 | 95±25 | <0.05 |
| Systolic blood pressure, mmHg | 102±14.3 | 98±15.7 | 105±12.8 | 0.44 |
| Arterial oxygen saturation, % | 84±12 | 78±15 | 90±9 | <0.05 |
| TP53, ng/L | 5.25±0.65 | 10.20±1.20 | 0.30±0.10 | <0.001 |
| NT-proBNP, ng/L(M) | 306.6 | 505.3 | 107.8 | <0.001 |
| cTnI, μg/L | 0.13±0.04 | 0.23±0.13 | 0.02±0.01 | <0.001 |
| CK-MB,IU/L | 20.27±4.71 | 28.30±5.13 | 12.24±4.29 | <0.001 |
| Plasma glucose, mmol/L | 6.5±1.2 | 6.8±1.6 | 6.2±0.8 | 0.57 |
| Alanine transaminase, U/L | 57±15 | 66±13 | 48±17 | <0.05 |
| C reaction protein, mg/L | 28±6.9 | 31±6.5 | 25±7.3 | <0.05 |
| Procalcitonin, mg/L | 5±2.9 | 6±3.5 | 4±2.3 | <0.05 |
| Blood lactic acid, mmol/L | 3±1.3 | 3±1.5 | 3±1.1 | 0.67 |
| Ejection fraction, % | 55±3.1 | 45±3.8 | 65±2.4 | <0.05 |
| E peak/A peak | 1.4±0. | 1.5±0.2 | 1.3±0.2 | 0.26 |