30 June 2022 : Clinical Research
Nomogram for Prediction of Postoperative Morbidity in Patients with Colon Cancer Requiring Emergency Therapy
Raul Mihailov1ABCDEFG, Dorel Firescu1AEF, Georgiana Bianca Constantin2BDEF, Cristina Șerban1BEF, Eugenia Panaitescu3CDE, Cristian Marica
4BEF, Rodica Bîrlă5ADEF*, Traian Patrascu5DEF
DOI: 10.12659/MSM.936303
Med Sci Monit 2022; 28:e936303
Table 1 Univariate analysis results of relationship between clinicopathological characteristics and postoperative complications in patients undergoing emergency surgery for complicated colon cancer.
| PO COMPL=yes | PO COMPL=no | p value | ||
|---|---|---|---|---|
| Age | >68 years | 71/106 (67.0%) | 174/343 (50.7%) | * |
| ≤68 years | 35/106 (33.0%) | 169/343 (49.3%) | ||
| SEX | F | 38/106 (35.8%) | 137/343 (39.9%) | * |
| M | 68/106 (64.2%) | 206/343 (60.1%) | ||
| DAVIES Score | 1 | 40/106 (37.7%) | 145/343 (42.3%) | # |
| 2 | 36/106 (34%) | 142/343 (41.4%) | ||
| 3 | 26/106 (24.5%) | 52/343 (15.2%) | ||
| 4 | 3/106 (2.8%) | 4/343 (1.2%) | ||
| 6 | 1/106 (0.9%) | 0/343 (0.0%) | ||
| CHARLSON Score | ≤3 | 47/106 (44.3%) | 227/343 (66.2%) | * |
| >3 | 59/106 (55.7%) | 116/343 (33.6%) | ||
| Age-ajusted CHARLSON Score | ≤9 | 28/106 (26.4%) | 169/343 (49.3%) | * |
| >9 | 78/106 (73.6%) | 174/343 (50.4%) | ||
| Onset | ≤1 day | 5/106 (4.7%) | 24/343 (7.0%) | * |
| 2–5 days | 30/106 (28.3%) | 155/343 (45.2%) | ||
| 6–14 days | 57/106 (53.8%) | 136/343 (39.7%) | ||
| >14 days | 14/106 (13.2%) | 28/343 (8.1%) | ||
| ECOG | 0 | 8/106 (7.5%) | 75/343 (21,9%) | * |
| 1 | 14/106 (13.2%) | 60/343 (17.4%) | ||
| 2 | 45/106 (42.5%) | 137/343 (40%) | ||
| 3 | 20/106 (18.9%) | 57/343 (16.8%) | ||
| 4 | 19/106 (17.9%) | 14/343 (4.1%) | ||
| Cachexia | Yes | 48/106 (45.3%) | 50/343 (14.6%) | * |
| WBC | P | 81/106 (76.4%) | 122/343 (35.6%) | * |
| Anemia | Yes | 86/106 (81.1%) | 210/343 (61.2%) | * |
| Platelets | P | 33/106 (31.1%) | 33/343 (9.6%) | * |
| Glycemia | P | 31/106 (29.2%) | 69/343 (20.0%) | * |
| Creatinine | P | 64/106 (60.4%) | 113/343 (32.9%) | * |
| Electrolyte disturbance | Yes | 54/106 (50.9%) | 81/343 (23.6%) | * |
| Acidosis | Yes | 39/106 (36.8%) | 59/343 (17.2%) | * |
| Coagulation disturbance | Yes | 28/106 (26.4%) | 25/343 (7.2%) | * |
| Sepsis | Yes | 24/105 (22.9%) | 17/343 (5.0%) | * |
| Preop diagnosis | H | 2/106 (1.9%) | 14/343 (4.1%) | * |
| O | 75/106 (70.8%) | 301/343 (87.8%) | ||
| P | 29/106 (27.4%) | 28/343 (8.2%) | ||
| Location | C18.0 | 12/106 (11.3%) | 30/343 (8.7%) | * |
| C18.2 | 6/106 (5.7%) | 14/343 (4.1%) | ||
| C18.3 | 8/106 (7.5%) | 25/343 (7.2%) | ||
| C18.4 | 13/106 (12.3%) | 28/343 (8.1%) | ||
| C18.5 | 9/106 (8.5%) | 35/343 (10.1%) | ||
| C18.6 | 9/106 (8.5%) | 38/343 (11%) | ||
| C18.7 | 39/106 (36.8%) | 120/343 (35.0%) | ||
| C19.0 | 10/106 (9.4%) | 53/343 (15.5%) | ||
| IO COMPL | Yes | 17/106 (16.0%) | 30/343 (8.7%) | * |
| Metastasis | Yes | 32/106 (30.2%) | 63/343 (18.4%) | * |
| History of abdominal surgery | Yes | 44/106 (41.5%) | 103/343 (30.0%) | * |
| Operation type | 1 | 13/106 (12.3%) | 60/343 (17.5%) | * |
| 2 | 41/106 (38.7%) | 128/343 (37.3%) | ||
| 3 | 12/106 (11.3%) | 29/343 (8.5%) | ||
| 4 | 40/106 (37.7%) | 126/343 (36.7%) | ||
| Operating time | 1 h | 5/106 (4.7%) | 16/343 (4.7%) | * |
| 1.5 h | 10/106 (9.4%) | 56/343 (16.3%) | ||
| 2 h | 36/106 (34.0%) | 204/343 (59.5%) | ||
| 2.5 h | 25/106 (23.6%) | 35/343 (10.2%) | ||
| 3 h | 24/106 (22.6%) | 25/343 (7.3%) | ||
| 3.5 h | 2/106 (1.9%) | 1/343 (0.3%) | ||
| 4 h | 2/106 (1.9%) | 2/343 (0.6%) | ||
| 4.5 h | 1/106 (0.9%) | 1/343 (0.3%) | ||
| 5 h | 1/106 (0.9%) | 3/343 (0.9%) | ||
| Abdominal closure | Open | 3/106 (2.8%) | 0/343 (0.0%) | * |
| Closed | 94/106 (88.7%) | 340/343 (99.1%) | ||
| Semi-open | 9/106 (8.5%) | 3/343 (0.9%) | ||
| Antibiotic | 1 | 49/106 (46.2%) | 221/343 (64.4%) | * |
| 2 | 31/106 (29.2%) | 90/343 (26.1%) | ||
| 3 | 12/106 (11.3%) | 20/343 (5.8%) | ||
| 4 | 14/106 (13.2%) | 12/343 (3.5%) | ||
| * Pearson chi-square; # likelihood ratio. PO COMPL – postoperative complications; Onset – duration from onset of symptoms to admission; ECOG – Eastern Cooperative Oncology Group performance status; WBC – white blood cell count; H – lower gastrointestinal hemorrhage; O – intestinal occlusion; P – peritonitis; C18.0 – cecum; C18.2 – ascending colon; C18.3 – hepatic flexure of colon; C18.4 – transverse colon; C18.5 – splenic flexure of colon; C18.6 – descending colon; C18.7 – sigmoid; C19 – rectosigmoid junction; IO COMPL – intraoperative complications; operation type 1 – colostomy; operation type 2 – colic resection with stoma; operation type 3 – internal by-pass; operation type 4 – colic resection with anastomosis; h – hours; P – pathologic value. | ||||