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30 June 2022: Clinical Research

Nomogram for Prediction of Postoperative Morbidity in Patients with Colon Cancer Requiring Emergency Therapy

Raul Mihailov 1ABCDEFG , Dorel Firescu 1AEF , Georgiana Bianca Constantin 2BDEF , Cristina Şerban 1BEF , Eugenia Panaitescu 3CDE , Cristian Marica 4BEF , Rodica Bîrlă 5ADEF* , Traian Patrascu 5DEF

DOI: 10.12659/MSM.936303

Med Sci Monit 2022; 28:e936303

Table 1 Univariate analysis results of relationship between clinicopathological characteristics and postoperative complications in patients undergoing emergency surgery for complicated colon cancer.

PO COMPL=yesPO COMPL=nop value
Age>68 years71/106 (67.0%)174/343 (50.7%)*
≤68 years35/106 (33.0%)169/343 (49.3%)
SEXF38/106 (35.8%)137/343 (39.9%)*
M68/106 (64.2%)206/343 (60.1%)
DAVIES Score140/106 (37.7%)145/343 (42.3%)#
236/106 (34%)142/343 (41.4%)
326/106 (24.5%)52/343 (15.2%)
43/106 (2.8%)4/343 (1.2%)
61/106 (0.9%)0/343 (0.0%)
CHARLSON Score≤347/106 (44.3%)227/343 (66.2%)*
>359/106 (55.7%)116/343 (33.6%)
Age-ajusted CHARLSON Score≤928/106 (26.4%)169/343 (49.3%)*
>978/106 (73.6%)174/343 (50.4%)
Onset≤1 day5/106 (4.7%)24/343 (7.0%)*
2–5 days30/106 (28.3%)155/343 (45.2%)
6–14 days57/106 (53.8%)136/343 (39.7%)
>14 days14/106 (13.2%)28/343 (8.1%)
ECOG08/106 (7.5%)75/343 (21,9%)*
114/106 (13.2%)60/343 (17.4%)
245/106 (42.5%)137/343 (40%)
320/106 (18.9%)57/343 (16.8%)
419/106 (17.9%)14/343 (4.1%)
CachexiaYes48/106 (45.3%)50/343 (14.6%)*
WBCP81/106 (76.4%)122/343 (35.6%)*
AnemiaYes86/106 (81.1%)210/343 (61.2%)*
PlateletsP33/106 (31.1%)33/343 (9.6%)*
GlycemiaP31/106 (29.2%)69/343 (20.0%)*
CreatinineP64/106 (60.4%)113/343 (32.9%)*
Electrolyte disturbanceYes54/106 (50.9%)81/343 (23.6%)*
AcidosisYes39/106 (36.8%)59/343 (17.2%)*
Coagulation disturbanceYes28/106 (26.4%)25/343 (7.2%)*
SepsisYes24/105 (22.9%)17/343 (5.0%)*
Preop diagnosisH2/106 (1.9%)14/343 (4.1%)*
O75/106 (70.8%)301/343 (87.8%)
P29/106 (27.4%)28/343 (8.2%)
LocationC18.012/106 (11.3%)30/343 (8.7%)*
C18.26/106 (5.7%)14/343 (4.1%)
C18.38/106 (7.5%)25/343 (7.2%)
C18.413/106 (12.3%)28/343 (8.1%)
C18.59/106 (8.5%)35/343 (10.1%)
C18.69/106 (8.5%)38/343 (11%)
C18.739/106 (36.8%)120/343 (35.0%)
C19.010/106 (9.4%)53/343 (15.5%)
IO COMPLYes17/106 (16.0%)30/343 (8.7%)*
MetastasisYes32/106 (30.2%)63/343 (18.4%)*
History of abdominal surgeryYes44/106 (41.5%)103/343 (30.0%)*
Operation type113/106 (12.3%)60/343 (17.5%)*
241/106 (38.7%)128/343 (37.3%)
312/106 (11.3%)29/343 (8.5%)
440/106 (37.7%)126/343 (36.7%)
Operating time1 h5/106 (4.7%)16/343 (4.7%)*
1.5 h10/106 (9.4%)56/343 (16.3%)
2 h36/106 (34.0%)204/343 (59.5%)
2.5 h25/106 (23.6%)35/343 (10.2%)
3 h24/106 (22.6%)25/343 (7.3%)
3.5 h2/106 (1.9%)1/343 (0.3%)
4 h2/106 (1.9%)2/343 (0.6%)
4.5 h1/106 (0.9%)1/343 (0.3%)
5 h1/106 (0.9%)3/343 (0.9%)
Abdominal closureOpen3/106 (2.8%)0/343 (0.0%)*
Closed94/106 (88.7%)340/343 (99.1%)
Semi-open9/106 (8.5%)3/343 (0.9%)
Antibiotic149/106 (46.2%)221/343 (64.4%)*
231/106 (29.2%)90/343 (26.1%)
312/106 (11.3%)20/343 (5.8%)
414/106 (13.2%)12/343 (3.5%)
* Pearson chi-square;
# likelihood ratio.
PO COMPL – postoperative complications; Onset – duration from onset of symptoms to admission; ECOG – Eastern Cooperative Oncology Group performance status; WBC – white blood cell count; H – lower gastrointestinal hemorrhage; O – intestinal occlusion; P – peritonitis; C18.0 – cecum; C18.2 – ascending colon; C18.3 – hepatic flexure of colon; C18.4 – transverse colon; C18.5 – splenic flexure of colon; C18.6 – descending colon; C18.7 – sigmoid; C19 – rectosigmoid junction; IO COMPL – intraoperative complications; operation type 1 – colostomy; operation type 2 – colic resection with stoma; operation type 3 – internal by-pass; operation type 4 – colic resection with anastomosis; h – hours; P – pathologic value.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750