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10 June 2022: Clinical Research

Association Between Serum Homocysteine Levels and Severity of Diabetic Kidney Disease in 489 Patients with Type 2 Diabetes Mellitus: A Single-Center Study

Juan Wu 1ABCDEF* , Dengke Liu 12BC* , Liu Yang 3B , Jianping Liu 1BC*

DOI: 10.12659/MSM.936323

Med Sci Monit 2022; 28:e936323

Table 4 Hcy was an independent risk factor for CKD stages 2–5 among the patients with T2DM.

Crude OR (95% CI)Adjusted OR (95% CI)
Model 1Model 2
T2DM111
DKD group1.196 (1.160, 1.234)*** 1.175 (1.138, 1.214)*** 1.136 (1.071, 1.204)***
CKD stage 11.008 (0.958,1.062)0.983 (0.930,1.040)0.991 (0.904, 1.086)
CKD stage 21.181 (1.122, 1.243)*** 1.147 (1.085,1.213)*** 1.090 (1.006, 1.181)*
CKD stage 31.328 (1.265, 1.395)*** 1.303 (1.238, 1.372)*** 1.187 (1.107, 1.271)***
CKD stage 41.427 (1.354, 1.504)*** 1.416 (1.341, 1.495)*** 1.262 (1.170, 1.362)***
CKD stage 51.494 (1.414, 1.578)*** 1.480 (1.397, 1.567)*** 1.356 (1.250, 1.471)***
adjusted for sex, age, and BMI; adjusted for model 1 variables+ SBP, DBP, FPG level, FCP level, HbA1c level, TC level, TG level, HDL level, LDL level, SUA level, UACR, folic acid level, vitamin B12 level, duration of diabetes mellitus, and history of hypertension; Hcy – homocysteine; OR – odds ratio; CI – confidence interval; T2DM – type 2 diabetes mellitus; DKD – diabetic kidney disease; CKD – chronic kidney disease; BMI – body mass index; SBP – systolic blood pressure; DBP – diastolic blood pressure; FPG – fasting plasma glucose; FCP – fasting C peptide; HbA1c – glycosylated hemoglobin A1c; TC – total cholesterol; TG – triglyceride; HDL – high-density lipoprotein; LDL – low-density lipoprotein; SUA – serum uric acid; UACR – urinary albumin/creatinine ratio;
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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750