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10 June 2022: Clinical Research

Association Between Serum Homocysteine Levels and Severity of Diabetic Kidney Disease in 489 Patients with Type 2 Diabetes Mellitus: A Single-Center Study

Juan Wu 1ABCDEF* , Dengke Liu 12BC* , Liu Yang 3B , Jianping Liu 1BC*

DOI: 10.12659/MSM.936323

Med Sci Monit 2022; 28:e936323

Table 5 Hcy was not an independent risk factor for albuminuria stages among the patients with T2DM.

Crude OR (95% CI)Adjusted OR (95% CI)
Model 1Model 2
DKD group1.196 (1.160, 1.234)*** 1.104 (1.066, 1.144)*** 1.021 (0.984, 1.060)
Stage A11.251 (1.203, 1.302)*** 1.104 (1.052, 1.158)*** 0.964 (0.909, 1.022)
Stage A21.155 (1.116, 1.195)*** 1.084 (1.044, 1.126)*** 1.024 (0.985, 1.065)
Stage A31.242 (1.199, 1.286)*** 1.126 (1.081, 1.172)*** 0.994 (0.945, 1.044)
Adjusted for sex, age, SBP, DBP, FPG level, FCP level, HbA1c level, TC level, TG level, HDL level, LDL level, SUA level, folic acid level, vitamin B12 level, duration of diabetes mellitus, and history of hypertension; Adjusted for model 1 variables+ eGFR; Hcy, homocysteine; OR – odds ratio; CI – confidence interval; T2DM – type 2 diabetes mellitus; DKD – diabetic kidney disease; SBP – systolic blood pressure; DBP – diastolic blood pressure; FPG – fasting plasma glucose; FCP – fasting C peptide; HbA1c – glycosylated hemoglobin A1c; TC – total cholesterol; TG – triglyceride; HDL – high-density lipoprotein; LDL – low-density lipoprotein; eGFR – estimated glomerular filtration rate; SUA – serum uric acid;
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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750