04 July 2022: Clinical Research
Post-Kidney Transplantation Results After Circulatory or Brain Death Without Pre-Mortem Heparin Administration
Jan Roman 12ABDEF , František Jalůvka 12ABE , Petr Ostruszka 1A , Petr Jelínek 12EF , Ján Hrubovčák 1B , Pavel Havránek 13BDF , Adéla Vrtková 45BCD , Zdeněk Lys 3BE , Jarmila Dědochová 3AB , Václav Procházka 26EG*DOI: 10.12659/MSM.936877
Med Sci Monit 2022; 28:e936877
Table 2 Paraclinical parameters of kidney donors.
| Parameter | Median (IQR) or n (%)i | P-valueiv | |
|---|---|---|---|
| DBDii (n=77) | DCDiii (n=17) | ||
| Serum creatinine (μmol/l) | 88 (65–115) | 85 (68–99) | 0.713 |
| eGFRv (ml/s/1,73 m) | 1.33 (0.93–1.72) | 1.13 (1.04–1.63) | 0.643 |
| Norepinephrine (mg/kg/min) | 0.18 (0.09–0.51) | 0.11 (0.00–0.36) | 0.079 |
| Hourly urine output (ml) | 200 (133–261) | 135 (103–210) | 0.139 |
| Time from insult to transplantation (days) | – | 4 (2–6) | – |
| Time from WLST to meeting fWIT criteria (minutes)vi | – | 4 (1–6) | – |
| Time from therapy withdrawal to cardiac arrest (minutes) | – | 11 (8–16) | – |
| No-touch interval duration (minutes) | – | 5 (5–5) | – |
| Time from beginning of WIT to OR arrival (minutes)ix | – | 17 (15–20) | – |
| Time from beginning of WIT to the beginning of perfusion (minutes) | – | 21 (18–25) | – |
| i The median with the interquartile range or the absolute frequency and relative frequency in percentages; ii DBD – Donors after Brain Death; iii DCD – Donors after Circulatory Death; iv The p-value of the Mann-Whitney test; v eGFR – Estimated Glomerular Filtration Rate from the creatinine concentration; vi WLST – withdrawal of life-sustaining therapy; vii fWIT – functional warm ischemia time; viii The criteria for reaching the start of WIT are described in the section; ix OR – Operating Room. | |||