Expression of the GZMB Gene Polymorphism, SNP rs8192917, in 990 Han Chinese Patients with Postoperative Keloids

Xiulin Wen; Huicong Du; Xiaoyan Hao; Jingrong Wang; Yuan Guo

doi:10.12659/MSM.936963

23 June 2022: Clinical Research

Expression of the Gene Polymorphism, SNP rs8192917, in 990 Han Chinese Patients with Postoperative Keloids

Xiulin Wen ^12CDE , Huicong Du ^1BF , Xiaoyan Hao ^1BF , Jingrong Wang ^3BF , Yuan Guo ^1AG*

DOI: 10.12659/MSM.936963

Med Sci Monit 2022; 28:e936963

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Background Material and Methods Results Discussion Conclusions References

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Supplementary Table 2 eQTL signals obtained for SNP rs8192917 on GZMB in 46 types of human tissues.

Gene	SNP	P	NES	T-statistic	Tissue
	rs8192917	1.20×10	0.240	4.400	Nerve – Tibial
	rs8192917	0.002	0.360	3.100	Brain – Cerebellar Hemisphere
	rs8192917	0.006	0.130	2.800	Adipose – Visceral (Omentum)
	rs8192917	0.008	0.054	2.600	Whole Blood
	rs8192917	0.024	0.140	2.300	Artery – Aorta
	rs8192917	0.032	0.160	2.200	Liver
	rs8192917	0.035	0.140	2.100	Pancreas
	rs8192917	0.040	−0.110	−2.100	Skin – Sun Exposed (Lower leg)
	rs8192917	0.048	0.092	2.000	Muscle – Skeletal
	rs8192917	0.064	0.240	1.900	Brain – Substantia nigra
	rs8192917	0.070	0.076	1.800	Adipose – Subcutaneous
	rs8192917	0.074	0.079	1.800	Esophagus – Mucosa
	rs8192917	0.090	0.140	1.700	Spleen
	rs8192917	0.095	0.065	1.700	Lung
	rs8192917	0.120	0.170	1.600	Minor Salivary Gland
	rs8192917	0.130	0.074	1.500	Stomach
	rs8192917	0.190	0.095	1.300	Artery – Coronary
	rs8192917	0.190	0.160	1.300	Cells – EBV-transformed lymphocytes
	rs8192917	0.200	0.100	1.300	Pituitary
	rs8192917	0.210	0.073	1.200	Esophagus – Muscularis
	rs8192917	0.260	0.059	1.100	Breast – Mammary Tissue
	rs8192917	0.280	0.056	1.100	Heart – Left Ventricle
	rs8192917	0.300	0.110	1.100	Brain – Hypothalamus
	rs8192917	0.340	−0.077	−0.950	Testis
	rs8192917	0.350	0.100	0.950	Brain – Putamen (basal ganglia)
	rs8192917	0.370	0.054	0.890	Skin – Not Sun Exposed (Suprapubic)
	rs8192917	0.390	0.065	0.850	Adrenal Gland
	rs8192917	0.420	0.066	0.800	Small Intestine – Terminal Ileum
	rs8192917	0.460	0.062	0.740	Prostate
	rs8192917	0.490	0.067	0.700	Brain – Caudate (basal ganglia)
	rs8192917	0.500	−0.074	−0.670	Brain – Cortex
	rs8192917	0.580	−0.064	−0.560	Vagina
	rs8192917	0.590	−0.060	−0.550	Brain – Frontal Cortex (BA9)
	rs8192917	0.620	0.023	0.500	Thyroid
	rs8192917	0.640	−0.051	−0.470	Ovary
	rs8192917	0.660	−0.059	−0.450	Uterus
	rs8192917	0.790	0.028	0.270	Brain – Nucleus accumbens (basal ganglia)
	rs8192917	0.800	−0.012	−0.260	Colon – Transverse
	rs8192917	0.800	0.013	0.250	Heart – Atrial Appendage
	rs8192917	0.820	0.034	0.230	Brain – Spinal cord (cervical c-1)
	rs8192917	0.840	0.014	0.200	Colon – Sigmoid
	rs8192917	0.910	0.012	0.110	Brain – Anterior cingulate cortex (BA24)
	rs8192917	0.930	−0.012	−0.090	Brain – Amygdala
	rs8192917	0.940	−0.003	−0.073	Artery – Tibial
	rs8192917	0.950	0.008	0.069	Brain – Cerebellum
	rs8192917	0.980	0.003	0.030	Brain – Hippocampus
NES – normalized effect size. Threshold of value was 0.05/46≈0.001.

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Expression of the Gene Polymorphism, SNP rs8192917, in 990 Han Chinese Patients with Postoperative Keloids

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