21 June 2022 : Clinical Research
Prognostic Significance of Preoperative Integrated Liver Inflammatory Score in Patients with Hepatocellular Carcinoma
Biao Wu12ABCDEF, Yumeng Wu
2ABC, Xianlin Guo12BCF, Yifei Liu3ACD, Yanping Yue2BCF, Wenjing Zhao2ABG, Jibin Liu2ADG, Xuming Wu4ABC, Aiguo Shen2ACEG*, Suqing Zhang1ACEFG
DOI: 10.12659/MSM.937005
Med Sci Monit 2022; 28:e937005
Table 2 Univariate and multivariate analyses of prognostic factors with OS in patients with HCC.
| Variable | Training cohort | |||
|---|---|---|---|---|
| Univariate | Multivariate | |||
| HR (95% CI) | P | HR (95% CI) | P | |
| ILIS (high vs low) | 0.554 (0.375–0.818) | 0.665 (0.444–0.997) | ||
| Age (<55 years vs ≥55 years) | 1.235 (0.866–1.761) | 0.244 | ||
| Gender ( male vs female) | 1.296 (0.654–2.565) | 0.457 | ||
| HBV (absent vs present) | 0.817 (0.569–1.173) | 0.273 | ||
| Cirrhosis (absent vs present) | 0.708 (0.490–1.023) | 0.066 | ||
| Tumour size (<5 cm vs 5–10 cm vs >10 cm) | 0.301 (0.174–0.520) | 0.465 (0.260–0.833) | ||
| No. of tumour nodules (1 vs ≥2) | 0.629 (0.402–0.983) | |||
| Differentiation (well vs moderate vs poor) | 1.295 (1.006–1.669) | |||
| Vascular tumor thrombus (absent vs present) | 0.560 (0.383–0.820) | |||
| Child-Pugh class (A vs B) | 0.889 (0.621–1.273) | 0.520 | ||
| BCLC stage (0 vs A vs B) | 4.040 (2.107–7.745) | 0.516 (0.318–0.839) | ||
| ILIS (high vs low) | 3.566 (1.694–7.507) | 0.574 (0.343–0.961) | ||
| Age (<55 years vs ≥55 years) | 1.097 (0.686–1.754) | 0.700 | ||
| Gender ( male vs female) | 1.225 (0.682–2.200) | 0.498 | ||
| HBV (absent vs present) | 0.815 (0.505–1.315) | 0.403 | ||
| Cirrhosis (absent vs present) | 1.281 (0.762–2.152) | 0.350 | ||
| Tumour size (<5 cm vs 5–10 cm vs >10 cm) | 1.493 (1.021–2.184) | |||
| No. of tumour nodules (1 vs ≥2) | 2.021 (1.061–3.852) | |||
| Differentiation (well vs moderate vs poor) | 1.418 (0.984–2.044) | 0.061 | ||
| Vascular tumor thrombus (absent vs present) | 2.001 (1.158–3.460) | |||
| Child-Pugh class (A vs B) | 0.680 (0.248–1.867) | 0.454 | ||
| BCLC stage (0 vs A vs B) | 0.424 (0.251–0.715) | 0.498 (0.282–0.879) | ||