Prognostic Significance of Preoperative Integrated Liver Inflammatory Score in Patients with Hepatocellular Carcinoma

Biao Wu; Yumeng Wu; Xianlin Guo; Yifei Liu; Yanping Yue; Wenjing Zhao; Jibin Liu; Xuming Wu; Aiguo Shen; Suqing Zhang

doi:10.12659/MSM.937005

21 June 2022 : Clinical Research

Prognostic Significance of Preoperative Integrated Liver Inflammatory Score in Patients with Hepatocellular Carcinoma

Biao Wu^12ABCDEF, Yumeng Wu

^2ABC, Xianlin Guo^12BCF, Yifei Liu^3ACD, Yanping Yue^2BCF, Wenjing Zhao^2ABG, Jibin Liu^2ADG, Xuming Wu^4ABC, Aiguo Shen^2ACEG*, Suqing Zhang^1ACEFG

DOI: 10.12659/MSM.937005

Med Sci Monit 2022; 28:e937005

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Table 3 Univariate and multivariate analyses of prognostic factors with RFS in patients with HCC.

Variable	Training cohort
	Univariate		Multivariate
	HR (95% CI)	P	HR (95% CI)	P
ILIS (high vs low)	1.869 (1.131–3.059)
Age (<55 years vs ≥55 years)	1.434 (0.893–2.302)	0.136
Gender ( male vs female)	0.684 (0.396–1.180)	0.172
HBV (absent vs present)	0.661 (0.415–1.054)	0.082
Cirrhosis (absent vs present)	0.581 (0.364–0.925)
Tumour size (<5 cm vs 5–10 cm vs >10 cm)	2.048 (1.479–2.837)		0.448 (0.225–0.892)
No. of tumour nodules (1 vs ≥2)	1.517 (0.845–2.723)	0.163
Differentiation (well vs moderate vs poor)	1.505 (1.073–2.109)
Vascular tumor thrombus (absent vs present)	2.295 (1.423–3.701)		0.506 (0.311–0.823)
Child-Pugh class (A vs B)	0.657 (0.285–1.519)	0.326
BCLC stage (0 vs A vs B)	0.348 (0.196–0.617)		0.457 (0.251–0.834)



ILIS (high vs low)	3.566 (1.694–7.507)
Age (<55 years vs ≥55 years)	0.821 (0.367–1.834)	0.630
Gender ( male vs female)	1.887 (0.645–5.524)	0.246
HBV (absent vs present)	0.906 (0.402–2.043)	0.813
Cirrhosis (absent vs present)	0.954 (0.423–2.149)	0.909
Tumour size (<5 cm vs 5–10 cm vs >10 cm)	2.205 (1.221–3.983)
No. of tumour nodules (1 vs ≥2)	2.358 (0.554–10.004)	0.246
Differentiation (well vs moderate vs poor)	1.137 (0.606–2.134)	0.689
Vascular tumor thrombus (absent vs present)	3.384 (1.477–7.750)
Child-Pugh class (A vs B)	0.383 (0.130–1.124)	0.080
BCLC stage (0 vs A vs B)	0.280 (0.116–0.676)		0.247 (0.065–0.931)

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Prognostic Significance of Preoperative Integrated Liver Inflammatory Score in Patients with Hepatocellular Carcinoma

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