Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies

Zhiqi Zhang; Hongyi Wu; Tao Wang; Yao Liu; Chun Meng

doi:10.12659/MSM.937051

16 September 2022 : Review article

Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies

Zhiqi Zhang^1EF, Hongyi Wu^1F, Tao Wang^2A, Yao Liu^3F, Chun Meng^2AG*

DOI: 10.12659/MSM.937051

Med Sci Monit 2022; 28:e937051

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Background Cardiac Lipid Accumulation Inflammatory Response Associated with Hyperlipidemia Hyperlipidemia Leads to Oxidative Stress Changes in the Endoplasmic Reticulum and Mitochondria Caused by Hyperlipidemia Discussion Conclusions References

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Table 1 Major mechanism of myocardial injury induced by hyperlipidemia.

Major injuries	Lipid	Main reference
Proinflammatory	LDL, oxLDLFFA	[,,][,]²¹
Oxidative stress	oxLDLFFA	[–][]⁴⁸
Metabolism decreased	oxLDLFFA	[,][–]⁷⁴
LDL – low-density lipoprotein; FFA – free fatty acids; oxLDL – oxidized low-density lipoprotein.

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Mechanisms of Myocardial Damage Due to Hyperlipidemia: A Review of Recent Studies

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