25 July 2022: Database Analysis
Integrating Network Pharmacology, Molecular Docking, and Experimental Validation to Investigate the Mechanism of (−)-Guaiol Against Lung Adenocarcinoma
Yaoying Zeng 1E* , Yanbin Pan 1B* , Bo Zhang 1C , Yingbin Luo 1D , Jianhui Tian 1AF , Yuli Wang 1CD , Xudong Ju 2BF , Jianchun Wu 1A* , Yan Li 1A*DOI: 10.12659/MSM.937131
Med Sci Monit 2022; 28:e937131
Supplementary Table 4. The result of GO and KEGG enrichment analysis.
| ID | Description | Gene ratio | Bg ratio | ||
|---|---|---|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | 20.07.2021 | 354/8102 | ||
| hsa04141 | Protein processing in endoplasmic reticulum | 20.05.2021 | 171/8102 | ||
| hsa05215 | Prostate cancer | 20.04.2021 | 97/8102 | ||
| hsa04110 | Cell cycle | 20.04.2021 | 124/8102 | ||
| hsa04612 | Antigen processing and presentation | 20.03.2021 | 78/8102 | ||
| hsa04914 | Progesterone-mediated oocyte maturation | 20.03.2021 | 100/8102 | ||
| hsa04114 | Oocyte meiosis | 20.03.2021 | 129/8102 | ||
| hsa04915 | Estrogen signaling pathway | 20.03.2021 | 138/8102 | ||
| hsa05418 | Fluid shear stress and atherosclerosis | 20.03.2021 | 139/8102 | ||
| hsa04120 | Ubiquitin mediated proteolysis | 20.03.2021 | 140/8102 | ||
| hsa05022 | Pathways of neurodegeneration - multiple diseases | 20.05.2021 | 475/8102 | ||
| hsa03040 | Spliceosome | 20.03.2021 | 151/8102 | ||
| hsa05160 | Hepatitis C | 20.03.2021 | 157/8102 | ||
| hsa05165 | Human papillomavirus infection | 20.04.2021 | 331/8102 | ||
| hsa05134 | Legionellosis | 20.02.2021 | 57/8102 | ||
| hsa04510 | Focal adhesion | 20.03.2021 | 201/8102 | ||
| hsa05140 | Leishmaniasis | 20.02.2021 | 77/8102 | ||
| hsa04810 | Regulation of actin cytoskeleton | 20.03.2021 | 218/8102 | ||
| hsa04512 | ECM-receptor interaction | 20.02.2021 | 88/8102 | ||
| hsa05222 | Small cell lung cancer | 20.02.2021 | 92/8102 | ||
| hsa05131 | Shigellosis | 20.03.2021 | 246/8102 | ||
| hsa04657 | IL-17 signaling pathway | 20.02.2021 | 94/8102 | ||
| hsa04933 | AGE-RAGE signaling pathway in diabetic complications | 20.02.2021 | 100/8102 | ||
| hsa04659 | Th17 cell differentiation | 20.02.2021 | 107/8102 | ||
| hsa04670 | Leukocyte transendothelial migration | 20.02.2021 | 114/8102 | ||
| hsa04068 | FoxO signaling pathway | 20.02.2021 | 131/8102 | ||
| hsa05135 | Yersinia infection | 20.02.2021 | 137/8102 | ||
| hsa04151 | 1.36E-05 | 0.001519047 | 0.001214 | FN1/EGFR/HSP90AA1/YWHAZ/ITGA4/CDK2/HSP90AB1 | 7 |
| hsa04141 | 4.74E-05 | 0.002652306 | 0.002119 | VCP/HSP90AA1/HSPA5/HSP90AB1/CUL1 | 5 |
| hsa05215 | 8.08E-05 | 0.003014678 | 0.002408 | EGFR/HSP90AA1/CDK2/HSP90AB1 | 4 |
| hsa04110 | 0.000209 | 0.005864916 | 0.004685 | MCM2/YWHAZ/CDK2/CUL1 | 4 |
| hsa04612 | 0.00087 | 0.019482004 | 0.015564 | HSP90AA1/HSPA5/HSP90AB1 | 3 |
| hsa04914 | 0.001786 | 0.033332938 | 0.026629 | HSP90AA1/CDK2/HSP90AB1 | 3 |
| hsa04114 | 0.003687 | 0.051336929 | 0.041012 | YWHAZ/CDK2/CUL1 | 3 |
| hsa04915 | 0.004458 | 0.051336929 | 0.041012 | EGFR/HSP90AA1/HSP90AB1 | 3 |
| hsa05418 | 0.004549 | 0.051336929 | 0.041012 | HSP90AA1/VCAM1/HSP90AB1 | 3 |
| hsa04120 | 0.004641 | 0.051336929 | 0.041012 | UBC/CUL1/CUL7 | 3 |
| hsa05022 | 0.005042 | 0.051336929 | 0.041012 | VCP/UBC/FUS/APP/HSPA5 | 5 |
| hsa03040 | 0.005733 | 0.053504025 | 0.042743 | FUS/HNRNPU/U2AF2 | 3 |
| hsa05160 | 0.006388 | 0.055033564 | 0.043965 | EGFR/YWHAZ/CDK2 | 3 |
| hsa05165 | 0.007885 | 0.063080921 | 0.050394 | FN1/EGFR/ITGA4/CDK2 | 4 |
| hsa05134 | 0.008519 | 0.063604833 | 0.050812 | VCP/EEF1A1 | 2 |
| hsa04510 | 0.012561 | 0.087929521 | 0.070244 | FN1/EGFR/ITGA4 | 3 |
| hsa05140 | 0.015164 | 0.097201735 | 0.077652 | ITGA4/EEF1A1 | 2 |
| hsa04810 | 0.015622 | 0.097201735 | 0.077652 | FN1/EGFR/ITGA4 | 3 |
| hsa04512 | 0.01952 | 0.112474118 | 0.089852 | FN1/ITGA4 | 2 |
| hsa05222 | 0.02122 | 0.112474118 | 0.089852 | FN1/CDK2 | 2 |
| hsa05131 | 0.021516 | 0.112474118 | 0.089852 | EGFR/UBC/CUL1 | 3 |
| hsa04657 | 0.022093 | 0.112474118 | 0.089852 | HSP90AA1/HSP90AB1 | 2 |
| hsa04933 | 0.0248 | 0.120765971 | 0.096477 | FN1/VCAM1 | 2 |
| hsa04659 | 0.028122 | 0.131236173 | 0.104841 | HSP90AA1/HSP90AB1 | 2 |
| hsa04670 | 0.031614 | 0.141631452 | 0.113145 | ITGA4/VCAM1 | 2 |
| hsa04068 | 0.040766 | 0.175607639 | 0.140288 | EGFR/CDK2 | 2 |
| hsa05135 | 0.044211 | 0.183394284 | 0.146509 | FN1/ITGA4 | 2 |