20 June 2022 : Clinical Research
A Single-Center Retrospective Study to Compare the Efficacy and Safety of Modified FOLFIRINOX with S-1 as Adjuvant Chemotherapy in 71 Patients with Resected Pancreatic Carcinoma
Linhua Yao1ABCEF, Chengwu Tang2ABCEF, Wenming Feng2ABFG, Hanbin Dai2ABCE*DOI: 10.12659/MSM.937136
Med Sci Monit 2022; 28:e937136
Table 2 Chemotherapy-induced adverse events.
| Event | mFFX group | S-1 group | P value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Grade | Grade | ||||||||
| 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | ||
| Neutropenia | 14 | 13 | 5 | 2 | 17 | 14 | 5 | 1 | 0.5976 |
| Thrombocytopenia | 9 | 14 | 9 | 2 | 17 | 15 | 4 | 1 | 0.0372 |
| Anemia | 18 | 10 | 1 | 0 | 19 | 10 | 1 | 0 | 0.6863 |
| Fatigue | 16 | 4 | 2 | 0 | 18 | 13 | 1 | 0 | 0.0226 |
| Nausea/vomiting | 9 | 18 | 6 | 0 | 13 | 17 | 2 | 0 | 0.0337 |
| Diarrhea | 10 | 15 | 5 | 2 | 16 | 13 | 0 | 0 | 0.0018 |
| Elevated creatinine level | 4 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0.3393 |
| Elevated ALT/AST level | 4 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0.1388 |
| Elevated total serum bilirubin level | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0.2672 |
| Stomatitis | 6 | 4 | 4 | 0 | 4 | 5 | 2 | 0 | 0.2156 |
| Hand-foot syndrome | 1 | 1 | 0 | 0 | 4 | 2 | 2 | 0 | 0.0569 |
| Paresthesia | 6 | 5 | 2 | 0 | 3 | 4 | 4 | 0 | 0.6412 |
| ALT – alanine aminotransferase; AST – aspartate aminotransferase. | |||||||||