16 August 2022: Clinical Research
Hemoglobin/Red Blood Cell Distribution Width Ratio in Peripheral Blood Is Positively Associated with Prognosis of Patients with Primary Hepatocellular Carcinoma
Yue Fang 1ABCDEF , Xiaonan Sun 1BC , Lu Zhang 1DE , Yidan Xu 1B , Wen Zhu 2AEFG*DOI: 10.12659/MSM.937146
Med Sci Monit 2022; 28:e937146
Table 2 Comparative univariate survival analyses of 252 patients with HCC.
| Univariate analysis | Progression-free survival | Overall survival | ||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Age, Years (mean±SD) | 1.123 (0.872, 1.447) | 0.369 | 1.026 (0.746, 1.412) | 0.874 |
| Gender | 0.205 | 0.100 | ||
| Female | 1 | 1 | ||
| Male | 1.209 (0.901, 1.621) | 1.355 (0.944, 1.945) | ||
| Smoke | 0.643 | 0.613 | ||
| Yes | 1 | 1 | ||
| No | 1.065 (0.795, 1.427) | 1.094 (0.772, 1.552) | ||
| Drink | 0.002 | 0.268 | ||
| No | 1 | 1 | ||
| Yes | 1.615 (1.192, 2.186) | 1.299 (0.854, 1.769) | ||
| BMI | ||||
| ≤23.9 | 1 | 1 | ||
| >23.9 | 2.05 (1.497, 2.807) | 3.056 (1.73, 5.397) | ||
| CNLC | ||||
| I, II | 1 | 1 | ||
| III, IV | 14.036 (9.719, 20.269) | 4.492 (3.130, 6.448) | ||
| Surgery | ||||
| No | 1 | 1 | ||
| Yes | 66.67 (0.06, 0.037) | 2.624 (1.768, 3.893) | ||
| WBC | 0.288 | 0.985 | ||
| ≤8.65×10 | 1 | 1 | ||
| >8.65×10 | 1.259 (0.823, 1.924) | 1.015 (0.598, 1.689) | ||
| PBC | 0.021 | 0.078 | ||
| ≤3.09×10 | 1 | 1 | ||
| >3.09×10 | 1.722 (1.085, 2.733) | 1.704 (0.942, 3.080) | ||
| Hb (g/dL) | 0.012 | 0.031 | ||
| ≤11.4 | 1 | 1 | ||
| >11.4 | 1.571 (1.103, 2.238) | 1.552 (1.040, 2.316) | ||
| AFP (ng/mL) | ||||
| ≤25 | 1 | 1 | ||
| >25 | 6.280 (4.358, 9.050) | 3.270 (2.210, 4.837) | ||
| HBsAg | 0.010 | 0.035 | ||
| Negative | 1 | 1 | ||
| Positive | 1.520 (1.104, 2.093) | 1.601 (1.035, 2.477) | ||
| NLR | 0.002 | 0.095 | ||
| ≤3.85 | 1 | 1 | ||
| >3.85 | 1.508 (0.435, 0.823) | 1.385 (0.945, 2.030) | ||
| PLR | 0.155 | 0.630 | ||
| ≤171.08 | 1 | 1 | ||
| >171.08 | 1.24 (0.592, 1.087) | 1.095 (0.758, 1.581) | ||
| HRR | ||||
| ≤0.987 | 1 | 1 | ||
| >0.987 | 3.979 (2.955, 5.358) | 4.613 (3.236, 6.575) | ||