16 August 2022 : Clinical Research
Hemoglobin/Red Blood Cell Distribution Width Ratio in Peripheral Blood Is Positively Associated with Prognosis of Patients with Primary Hepatocellular Carcinoma
Yue Fang1ABCDEF, Xiaonan Sun1BC, Lu Zhang1DE, Yidan Xu1B, Wen Zhu2AEFG*DOI: 10.12659/MSM.937146
Med Sci Monit 2022; 28:e937146
Table 3 Comparative multivariate survival analyses of 252 patients with HCC.
| Univariate Analysis | Progression-free survival | Overall survival | ||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Drink | 0.094 | – | ||
| Yes | 1 | – | ||
| No | 1.333 (0.537, 1050) | – | ||
| BMI | 0.708 | 0.008 | ||
| ≤25 | 1 | 1 | ||
| >25 | 1.076 (0.63, 1.368) | 1.806 (1.166, 2.798) | ||
| CNLC stage | <0.001 | 0.010 | ||
| I, II | 1 | 1 | ||
| III, IV | 4.692 (2.899, 7.594) | 1.920 (1.168, 3.157) | ||
| Surgery | <0.001 | 0.025 | ||
| No | 1 | 1 | ||
| Yes | 34.483 (0.014, 0.061) | 1.876 (0.307, 0.925) | ||
| Platelet (/L) | 0.328 | – | ||
| ≤3.09×10 | 1 | – | ||
| >3.09×10 | 1.292 (0.773, 2.159) | – | ||
| Hb (g/dL) | 0.014 | <0.001 | ||
| ≤11.4 | 1 | 1 | ||
| >11.4 | 1.645 (0.408, 0.904) | 1.686 (0.385, 0.913) | ||
| AFP (ng/mL) | <0.001 | 0.023 | ||
| ≤20 | 1 | 1 | ||
| >20 | 3.873 (2.560, 5.858) | 1.765 (1.080, 2.886) | ||
| HBsAg | – | 0.946 | ||
| Negative | – | 1 | ||
| Positive | – | 10.173 (0.605, 1.598) | ||
| NLR | 0.646 | |||
| ≤3.85 | 1 | – | – | |
| >3.85 | 1.083 (0.656, 1.299) | – | ||
| HRR | <0.001 | <0.001 | ||
| ≤0.987 | 1 | 1 | ||
| >0.987 | 2.457 (0.280, 0.593) | 2.31 (0.281, 0.665) | ||