05 October 2022 : Clinical Research
Performance of Xpert MTB/RIF for Diagnosis of Tuberculosis in HIV-Infected People in China: A Retrospective, Single-Center Study
Guiju Gao1ACDEFG*, Chunyu Zhu2BCDEF, Yingchu Liu3BCDEF, Siyuan Yang
4AB, Jiang Xiao5ACD, Hongxin Zhao5CDF, Di Yang5CDF, Hongyuan Liang5BCF, Fang Wang5BDF, Liang Wu5BCF, Fujie Zhang5ACEF, Liang Ni5CF
DOI: 10.12659/MSM.937264
Med Sci Monit 2022; 28:e937264
Table 2 Performance of Xpert, AFB and T-SPOT in detecting PTB, EPTB and total cases.
| Sensitivity (95% CI, %) | Specificity (95% CI, %) | PPV (95% CI, %) | NPV (95% CI, %) | |
|---|---|---|---|---|
| PTB cases (n=145) | ||||
| Xpert | 82.0 (44.2–96.4) | 83.7 (74.7–88.5) | 82.8 (66.7–91.2) | 98.1 (92.7–99.6) |
| AFB | 61.0 (27.3–86.3)* | 72.6 (62.8–79.1) | 69.7 (49.8–83.2) | 96.7 (88.9–98.6) |
| T-SPOT.TB | 91.0 (54.1–99.4) | 16.6 (10.3–22.7)# | 6.7 (3.3–12.8) | 95.8 (76.8–99.7) |
| EPTB cases (n=32) | ||||
| Xpert | 100.0 (5.4–100.0) | 93.5 (77.1–98.8) | 66.7 (12.5–98.2) | 100.0 (85.4–100.0) |
| AFB | 100.0 (5.4–100.0) | 87.1 (69.2–95.7) | 80.0 (29.8–98.9) | 100.0 (84.4–100.0) |
| T-SPOT.TB | 100.0 (5.4–100.0) | 32.2 (17.3–51.4)# | 95.4 (75.1–99.7) | 100.0 (65.5–100.0) |
| Total (n=177) | ||||
| Xpret | 83.3 (50.8–97.5) | 84.2 (77.5–89.2) | 72.2 (54.5–85.2) | 98.5 (94.4–99.7)) |
| AFB | 58.3 (28.5–83.5)# | 76.3 (69.4–82.4) | 84.7 (70.5–93.1) | 96.1 (90.8–98.5) |
| T-SPOT.TB | 91.6 (59.7–99.5) | 21.2 (15.4–28.3)# | 7.8 (4.1–13.8) | 97.2 (83.7–99.8) |
| AFB – acid-fast bacilli; PPV – positive predictive value ; NPV – negative predictive value; TB – tuberculosis. * Fisher exact =0.021 for comparison the sensitivity of Xpert with that of AFB in PTB; # statistical differences between the sensitivity or specificity of Xpert or AFB and T-SPOT, chi-square test (χ), | ||||