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05 October 2022: Clinical Research

Performance of Xpert MTB/RIF for Diagnosis of Tuberculosis in HIV-Infected People in China: A Retrospective, Single-Center Study

Guiju Gao 1ACDEFG* , Chunyu Zhu 2BCDEF* , Yingchu Liu 3BCDEF* , Siyuan Yang 4AB* , Jiang Xiao 1ACD , Hongxin Zhao 1CDF , Di Yang 1CDF , Hongyuan Liang 1BCF , Fang Wang 1BDF , Liang Wu 1BCF , Fujie Zhang 1ACEF , Liang Ni 1CF

DOI: 10.12659/MSM.937264

Med Sci Monit 2022; 28:e937264

Table 2 Performance of Xpert, AFB and T-SPOT in detecting PTB, EPTB and total cases.

Sensitivity (95% CI, %)Specificity (95% CI, %)PPV (95% CI, %)NPV (95% CI, %)
PTB cases (n=145)
 Xpert82.0 (44.2–96.4)83.7 (74.7–88.5)82.8 (66.7–91.2)98.1 (92.7–99.6)
 AFB61.0 (27.3–86.3)* 72.6 (62.8–79.1)69.7 (49.8–83.2)96.7 (88.9–98.6)
 T-SPOT.TB91.0 (54.1–99.4)16.6 (10.3–22.7)# 6.7 (3.3–12.8)95.8 (76.8–99.7)
EPTB cases (n=32)
 Xpert100.0 (5.4–100.0)93.5 (77.1–98.8)66.7 (12.5–98.2)100.0 (85.4–100.0)
 AFB100.0 (5.4–100.0)87.1 (69.2–95.7)80.0 (29.8–98.9)100.0 (84.4–100.0)
 T-SPOT.TB100.0 (5.4–100.0)32.2 (17.3–51.4)# 95.4 (75.1–99.7)100.0 (65.5–100.0)
Total (n=177)
 Xpret83.3 (50.8–97.5)84.2 (77.5–89.2)72.2 (54.5–85.2)98.5 (94.4–99.7))
 AFB58.3 (28.5–83.5)# 76.3 (69.4–82.4)84.7 (70.5–93.1)96.1 (90.8–98.5)
 T-SPOT.TB91.6 (59.7–99.5)21.2 (15.4–28.3)# 7.8 (4.1–13.8)97.2 (83.7–99.8)
AFB – acid-fast bacilli; PPV – positive predictive value ; NPV – negative predictive value; TB – tuberculosis.
* Fisher exact =0.021 for comparison the sensitivity of Xpert with that of AFB in PTB;
# statistical differences between the sensitivity or specificity of Xpert or AFB and T-SPOT, chi-square test (χ),

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750