09 August 2022 : Animal Research
Label-Free Mass Spectrometry-Based Quantitative Proteomics to Evaluate the Effects of the Calcium-Sensing Receptor Agonist Cinacalcet on Protein Expression in Rat Brains and Livers
Ewa Bulska
1ABCDEFG*, Andrzej Gawor 1ABCDEFG, Anna Konopka 1CE, Grzegorz Wryk1B, Bożena Czarkowska-Pączek 2DEF, Zdzisław Gajewski 3A, Leszek Pączek4ACDEFG
DOI: 10.12659/MSM.937338
Med Sci Monit 2022; 28:e937338
Table 1 List of upregulated and downregulated protein expression after 21 days cinacalcet therapy in rat livers (FDR=1%; s0=1, adjusted P<0.01).
| Student’s t-test difference (protein fold) | Gene symbol | Protein description |
|---|---|---|
| 3.86 | Serotransferrin | |
| 2.93 | Microsomal glutathione S-transferase 2 | |
| 2.58 | Ergosterol biosynthesis 28 homolog | |
| 2.56 | Serine protease inhibitor A3N | |
| 2.47 | Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial | |
| 2.43 | Ig gamma-1 chain C region | |
| 2.15 | T-kininogen 2 | |
| 2.06 | 3-beta-hydroxysteroid-Delta(8) | |
| 2.06 | Fatty acid desaturase 2 | |
| 1.97 | T-kininogen 1 | |
| −1.81 | Eukaryotic translation initiation factor 4E | |
| −3.10 | Glutathione S-transferase | |
| −4.54 | 40S ribosomal protein S28 | |