Transcriptome Analysis of Peripheral Blood Mononuclear Cells Response in Patients with Severe COVID-19 Reveals Crucial Genes Regulating Protein Ubiquitination

29 August 2022 : Database Analysis

Jinfeng Huang^1ABCDEF, Ruobing Li^2EF, Jie Cheng^3B*, Peilin Zhen^1AB

DOI: 10.12659/MSM.937532

Med Sci Monit 2022; 28:e937532

Background Material and Methods Results Discussion Conclusions References

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Table 3 Biological processes enrichment analysis of genes in cluster 1.

Term	Genes	P-value	FDR
Protein ubiquitination	ITCH, TRIM21, RNF130, FBXO11, UBE2J1, ASB16	0.026×10	0.0138×10
Negative regulation of NF-kappaB transcription factor activity	ITCH, TRIM21	0.025	0.67
Protein ubiquitination involved in ubiquitin-dependent protein catabolic process	ITCH, ANAPC1	0.053	0.85
Ubiquitin-dependent protein catabolic process	ITCH, FBXO11	0.063	0.85

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