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07 November 2022: Database Analysis

Mechanism of Progesterone in Treatment of Traumatic Brain Injury Based on Network Pharmacology and Molecular Docking Technology

Chen Zheng 1ABCDEFG , Jian Gong 1CEF , Lili Zang 2CDEF , Daiying Song 2BCDF , Xinyue Ran 2CDF , Juncen Li 2BCDE , Bo Jiang 1DF , Jianli Xu 1BC , Qihua Wu 1ACDFG*

DOI: 10.12659/MSM.937564

Med Sci Monit 2022; 28:e937564

Table 1 Top 20 progesterone-related targets in descending order of standardized fit scores.

RankPDB IDTarget nameNumber of featuresFit scoreNormalized fit scorez’-score
11reu_vBone morphogenetic protein 232.9730.99110.980898
21okl_vCarbonic anhydrase 232.9340.9781.10765
32p3g_vMAP kinase-activated protein kinase 232.8980.96610.966279
52aa6_vMineralocorticoid receptor54.8060.96124.51104
62pit_vAndrogen receptor32.8790.95960.967023
72ocf_vEstrogen receptor32.8650.9550.931076
81a28_vProgesterone receptor43.8010.95023.28058
93eqm_vCytochrome P450 19A132.8310.94380.849743
101qyx_vEstradiol 17-beta-dehydrogenase 154.6920.93843.88391
121j96_vAldo-keto reductase family 1 member C232.7470.91560.488136
141xf0_vAldo-keto reductase family 1 member C332.7180.90590.668436
161e7a_vSerum albumin32.6490.88310.468333
171xdd_vIntegrin alpha-L32.630.87680.262544
182obj_vProto-oncogene serine/threonine-protein kinase Pim-132.5670.85550.165933
191zxc_vADAM 1743.3950.84881.79712
201l6l_vApolipoprotein A-II32.5240.84120.0122296

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750