07 November 2022: Database Analysis
Mechanism of Progesterone in Treatment of Traumatic Brain Injury Based on Network Pharmacology and Molecular Docking Technology
Chen Zheng 1ABCDEFG , Jian Gong 1CEF , Lili Zang 2CDEF , Daiying Song 2BCDF , Xinyue Ran 2CDF , Juncen Li 2BCDE , Bo Jiang 1DF , Jianli Xu 1BC , Qihua Wu 1ACDFG*DOI: 10.12659/MSM.937564
Med Sci Monit 2022; 28:e937564
Table 1 Top 20 progesterone-related targets in descending order of standardized fit scores.
| Rank | PDB ID | Target name | Number of features | Fit score | Normalized fit score | z’-score |
|---|---|---|---|---|---|---|
| 1 | 1reu_v | Bone morphogenetic protein 2 | 3 | 2.973 | 0.9911 | 0.980898 |
| 2 | 1okl_v | Carbonic anhydrase 2 | 3 | 2.934 | 0.978 | 1.10765 |
| 3 | 2p3g_v | MAP kinase-activated protein kinase 2 | 3 | 2.898 | 0.9661 | 0.966279 |
| 4 | 1dvz_v | Transthyretin | 3 | 2.894 | 0.9648 | 1.01366 |
| 5 | 2aa6_v | Mineralocorticoid receptor | 5 | 4.806 | 0.9612 | 4.51104 |
| 6 | 2pit_v | Androgen receptor | 3 | 2.879 | 0.9596 | 0.967023 |
| 7 | 2ocf_v | Estrogen receptor | 3 | 2.865 | 0.955 | 0.931076 |
| 8 | 1a28_v | Progesterone receptor | 4 | 3.801 | 0.9502 | 3.28058 |
| 9 | 3eqm_v | Cytochrome P450 19A1 | 3 | 2.831 | 0.9438 | 0.849743 |
| 10 | 1qyx_v | Estradiol 17-beta-dehydrogenase 1 | 5 | 4.692 | 0.9384 | 3.88391 |
| 11 | 2uzd_v | Cyclin-A2 | 3 | 2.787 | 0.9289 | 0.830167 |
| 12 | 1j96_v | Aldo-keto reductase family 1 member C2 | 3 | 2.747 | 0.9156 | 0.488136 |
| 13 | 1p49_v | Steryl-sulfatase | 3 | 2.719 | 0.9064 | 0.46795 |
| 14 | 1xf0_v | Aldo-keto reductase family 1 member C3 | 3 | 2.718 | 0.9059 | 0.668436 |
| 15 | 1shj_v | Caspase-7 | 3 | 2.685 | 0.8951 | 0.322237 |
| 16 | 1e7a_v | Serum albumin | 3 | 2.649 | 0.8831 | 0.468333 |
| 17 | 1xdd_v | Integrin alpha-L | 3 | 2.63 | 0.8768 | 0.262544 |
| 18 | 2obj_v | Proto-oncogene serine/threonine-protein kinase Pim-1 | 3 | 2.567 | 0.8555 | 0.165933 |
| 19 | 1zxc_v | ADAM 17 | 4 | 3.395 | 0.8488 | 1.79712 |
| 20 | 1l6l_v | Apolipoprotein A-II | 3 | 2.524 | 0.8412 | 0.0122296 |