07 November 2022 : Database Analysis
Mechanism of Progesterone in Treatment of Traumatic Brain Injury Based on Network Pharmacology and Molecular Docking Technology
Chen Zheng1ABCDEFG, Jian Gong1CEF, Lili Zang2CDEF, Daiying Song2BCDF, Xinyue Ran2CDF, Juncen Li2BCDE, Bo Jiang1DF, Jianli Xu1BC, Qihua Wu1ACDFG*DOI: 10.12659/MSM.937564
Med Sci Monit 2022; 28:e937564
Table 2 Binding energies of progesterone and key targets.
| Target | PDB ID | The binding energy/Kal·mol−1 |
|---|---|---|
| ALB | 4L9K | −7.1 |
| CASP3 | 4NBL | −5.9 |
| HSP90AA1 | 3K97 | −7.8 |
| EGFR | AW32 | −9.4 |
| ANXA5 | 5CCL | −9.2 |
| KDR | 4DLI | −7.4 |
| MAPK14 | 4F9Y | −8.4 |
| PPARG | 2ZNN | −8.4 |
| MAPK1 | 2B1P | −9.2 |
| IL2 | 5TOZ | −8.8 |