Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population

30 January 2023 : Clinical Research

Bo Ma^1ABDEF, Wenpei Zhang^2BC, Xiaochen Wang^2BC, Huili Jiang^3BF, Li Tang^3BF, Wen Yang^3BF, Qianyan Kang^4A*, Juan Cao^3BF

DOI: 10.12659/MSM.937702

Med Sci Monit 2023; 29:e937702

Background Material and Methods Results Discussion Conclusions References

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Table 3 Significant association signals identified from single marker based analyses.

CHR	SNP	POS	Loci	Test	Groups	Patients with high myopia (N=3,162)		OR [95% CI]	*χ2	P-value
CHR	SNP	POS	Loci	Test	Groups	Cataract+ (N=1,026)	Cataract− (N=2,136)	OR [95% CI]	*χ2	P-value
2	rs890069	12727378		GENO	CC	63 (6)	71 (3)	2.07 [1.46–2.95]
					CT	349 (34)	632 (30)	1.29 [1.10–1.51]
					TT	614 (60)	1,433 (67)	Ref	22.97	1.03×10
				ALLELIC	C	475 (23)	774 (18)	1.36 [1.20–1.55]
				ALLELIC	T	1,577 (77)	3,498 (82)	Ref	22.13	2.55×10
12	rs17739338	30731158		GENO	TT	2 (0.2)	7 (0.3)	0.57 [0.12–2.74]
					CT	51 (5)	192 (9)	0.53 [0.38–0.73]
					CC	973 (94.8)	1,937 (90.7)	Ref	–	0.0001
				ALLELIC	T	55 (3)	206 (5)	0.54 [0.40–0.74]
				ALLELIC	C	1,997 (97)	4,066 (95)	Ref	16.07	6.10×10
CHR – chromosome; POS – position; GENO – genotypic analysis; ALLELIC – allelic analysis; OR – odds ratio; CI – confidence interval. The values in brackets are percentages. ^* Fisher exact test was applied when necessary.

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