Polymorphisms in TRIB2 and CAPRIN2 Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population

Bo Ma; Wenpei Zhang; Xiaochen Wang; Huili Jiang; Li Tang; Wen Yang; Qianyan Kang; Juan Cao

doi:10.12659/MSM.937702

30 January 2023: Clinical Research

Polymorphisms in and Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population

Bo Ma ^1ABDEF* , Wenpei Zhang ^2BC* , Xiaochen Wang ^2BC* , Huili Jiang ^3BF , Li Tang ^3BF , Wen Yang ^3BF , Qianyan Kang ^1A* , Juan Cao ^3BF

DOI: 10.12659/MSM.937702

Med Sci Monit 2023; 29:e937702

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Table 7 eQTL signals between SNP rs17739338 and CAPRIN2 in multiple types of human tissues.

Gene	Variant ID	SNP	P-value	NES	T-statistic	Tissue
	chr12_30731158_C_T_b38	rs17739338	3.40E-10	−0.33	−6.4	Adipose – Subcutaneous
	chr12_30731158_C_T_b38	rs17739338	1.20E-09	−0.32	−6.2	Adipose – Visceral (Omentum)
	chr12_30731158_C_T_b38	rs17739338	4.2E-06	−0.41	−4.7	Adrenal Gland
	chr12_30731158_C_T_b38	rs17739338	4.20E-04	−0.19	−3.6	Artery – Aorta
	chr12_30731158_C_T_b38	rs17739338	1.00E-05	−0.37	−4.5	Artery – Coronary
	chr12_30731158_C_T_b38	rs17739338	5.1E-06	−0.2	−4.6	Artery – Tibial
	chr12_30731158_C_T_b38	rs17739338	0.0034	−0.35	−3	Brain – Amygdala
	chr12_30731158_C_T_b38	rs17739338	5.20E-05	−0.32	−4.2	Brain – Anterior cingulate cortex (BA24)
	chr12_30731158_C_T_b38	rs17739338	1.40E-07	−0.28	−5.5	Brain – Caudate (basal ganglia)
	chr12_30731158_C_T_b38	rs17739338	6.50E-10	−0.52	−6.7	Brain – Cerebellar Hemisphere
	chr12_30731158_C_T_b38	rs17739338	2.5E-06	−0.5	−4.9	Brain – Cerebellum
	chr12_30731158_C_T_b38	rs17739338	9.60E-05	−0.32	−4	Brain – Cortex
	chr12_30731158_C_T_b38	rs17739338	1.20E-07	−0.38	−5.6	Brain – Frontal Cortex (BA9)
	chr12_30731158_C_T_b38	rs17739338	0.0021	−0.21	−3.1	Brain – Hippocampus
	chr12_30731158_C_T_b38	rs17739338	0.0073	−0.27	−2.7	Brain – Hypothalamus
	chr12_30731158_C_T_b38	rs17739338	2.10E-08	−0.37	−5.9	Brain – Nucleus accumbens (basal ganglia)
	chr12_30731158_C_T_b38	rs17739338	2.00E-07	−0.33	−5.5	Brain – Putamen (basal ganglia)
	chr12_30731158_C_T_b38	rs17739338	5.70E-09	−0.57	−6.4	Brain – Spinal cord (cervical c-1)
	chr12_30731158_C_T_b38	rs17739338	0.0005	−0.29	−3.6	Brain – Substantia nigra
	chr12_30731158_C_T_b38	rs17739338	2.10E-07	−0.28	−5.3	Breast – Mammary Tissue
	chr12_30731158_C_T_b38	rs17739338	0.0019	−0.14	−3.1	Cells – Cultured fibroblasts
	chr12_30731158_C_T_b38	rs17739338	0.6500	−0.047	−0.46	Cells – EBV-transformed lymphocytes
	chr12_30731158_C_T_b38	rs17739338	1.5E-06	−0.32	−4.9	Colon – Sigmoid
	chr12_30731158_C_T_b38	rs17739338	5.00E-13	−0.31	−7.6	Colon – Transverse
	chr12_30731158_C_T_b38	rs17739338	6.20E-05	−0.19	−4	Esophagus – Mucosa
	chr12_30731158_C_T_b38	rs17739338	3.50E-12	−0.32	−7.2	Esophagus – Muscularis
	chr12_30731158_C_T_b38	rs17739338	1.90E-05	−0.38	−4.4	Heart – Atrial Appendage
	chr12_30731158_C_T_b38	rs17739338	0.0017	−0.24	−3.2	Heart – Left Ventricle
	chr12_30731158_C_T_b38	rs17739338	NaN	NaN	NaN	Kidney – Medulla
	chr12_30731158_C_T_b38	rs17739338	0.0070	−0.31	−2.7	Liver
	chr12_30731158_C_T_b38	rs17739338	1.10E-08	−0.4	−5.8	Lung
	chr12_30731158_C_T_b38	rs17739338	0.0005	−0.35	−3.6	Minor Salivary Gland
	chr12_30731158_C_T_b38	rs17739338	0.7900	0.014	0.27	Muscle – Skeletal
	chr12_30731158_C_T_b38	rs17739338	0.0032	−0.11	−3	Nerve – Tibial
	chr12_30731158_C_T_b38	rs17739338	0.0043	−0.29	−2.9	Ovary
	chr12_30731158_C_T_b38	rs17739338	4.30E-15	−0.49	−8.4	Pancreas
	chr12_30731158_C_T_b38	rs17739338	1.70E-18	−0.81	−9.7	Pituitary
	chr12_30731158_C_T_b38	rs17739338	6.5E-06	−0.43	−4.6	Prostate
	chr12_30731158_C_T_b38	rs17739338	6.60E-05	−0.17	−4	Skin – Not Sun Exposed (Suprapubic)
	chr12_30731158_C_T_b38	rs17739338	0.0045	−0.12	−2.9	Skin – Sun Exposed (Lower leg)
	chr12_30731158_C_T_b38	rs17739338	1.10E-08	−0.35	−6.1	Small Intestine – Terminal Ileum
	chr12_30731158_C_T_b38	rs17739338	1.00E-11	−0.55	−7.3	Spleen
	chr12_30731158_C_T_b38	rs17739338	1.30E-05	−0.29	−4.4	Stomach
	chr12_30731158_C_T_b38	rs17739338	3.5E-06	−0.22	−4.7	Testis
	chr12_30731158_C_T_b38	rs17739338	2.10E-32	−0.49	−13	Thyroid
	chr12_30731158_C_T_b38	rs17739338	3.80E-05	−0.38	−4.3	Uterus
	chr12_30731158_C_T_b38	rs17739338	0.0140	−0.18	−2.5	Vagina
	chr12_30731158_C_T_b38	rs17739338	0.0550	−0.076	−1.9	Whole Blood
NES – normalized effect size.

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Polymorphisms in and Genes Contribute to the Susceptibility to High Myopia-Induced Cataract in Han Chinese Population

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