30 August 2022 : Clinical Research
Postoperative Outcomes Following a Modified Method of Surgical Division of the Splenic Pedicle in 719 Patients During Splenectomy for Portal Hypertension: A 12-Year, Retrospective, Single-Center Study
Long Huang1ABDEFG*, Qingsheng Yu1DG, Hui Peng1BCF, Zhou Zhen2CDFDOI: 10.12659/MSM.937763
Med Sci Monit 2022; 28:e937763
Table 1 Comparison of the backgrounds of included patients between the 2 groups by PSM analysis.
| Variables | Unmatched | P | Matched | P | ||
|---|---|---|---|---|---|---|
| Control group (n=349) | Study group (n=370) | Control group (n=260) | Study group (n=260) | |||
| Age (years) | 32.7±15.0 | 33.5±14.7 | 0.47 | 32.8±15.0 | 33.2±14.8 | 0.77 |
| Sex, n (%) | 0.72 | 0.93 | ||||
| Male | 199 (57.0) | 206 (55.7) | 148 (56.9) | 147 (56.5) | ||
| Female | 150 (43.0) | 164 (44.3) | 112 (43.1) | 113 (43.5) | ||
| Etiology o cirrhosis, n (%) | 0.89 | 0.93 | ||||
| HLD cirrhosis | 267 (76.5) | 295 (79.7) | 205 (78.9) | 204 (78.5) | ||
| HBV cirrhosis | 62 (17.8) | 64 (17.3) | 41 (15.8) | 46 (17.7) | ||
| HCV cirrhosis | 9 (2.6) | 3 (0.8) | 8 (3.1) | 3 (1.2) | ||
| Schistosomiasis cirrhosis | 1 (0.3) | 2 (0.5) | 1 (0.4) | 2 (0.8) | ||
| Alcoholic cirrhosis | 1 (0.3) | 2 (0.5) | 1 (0.4) | 2 (0.8) | ||
| Autoimmunity cirrhosis | 7 (2.0) | 3 (0.8) | 2 (0.8) | 2 (0.8) | ||
| Unknown | 2 (0.6) | 1 (0.3) | 2 (0.8) | 1 (0.4) | ||
| Child-Pugh classification, n (%) | 0.19 | 0.65 | ||||
| A | 262 (75.1) | 259 (70.0) | 194 (74.6) | 187 (71.9) | ||
| B | 82 (23.5) | 107 (28.9) | 61 (23.5) | 70 (26.9) | ||
| C | 5 (1.4) | 4 (1.1) | 5 (1.9) | 3 (1.2) | ||
| The size of spleen (mm) | ||||||
| Longitudinal diameter of spleen | 180.3±33.0 | 176.5±30.6 | 0.11 | 175.8±31.5 | 178.0±31.6 | 0.41 |
| Thickness of spleen | 69.0±16.8 | 72.3±16.4 | 0.01 | 70.9±16.8 | 70.9±16.1 | 0.99 |
| The diameter of portal vein system (cm) | ||||||
| Portal vein | 1.5±0.2 | 1.4±0.2 | P<0.01 | 1.4±0.2 | 1.4±0.2 | 0.38 |
| Splenic vein6 | 1.3±0.5 | 1.2±0.3 | P<0.01 | 1.3±0.2 | 1.3±0.3 | 0.43 |
| Preoperative blood examination | ||||||
| WBC (10/L) | 2.8±1.7 | 3.0±2.0 | 0.11 | 2.8±1.6 | 2.8±1.4 | 0.78 |
| RBC (10/L) | 3.9±0.7 | 4.8±16.8 | 0.32 | 3.9±0.7 | 3.9±0.6 | 0.98 |
| HGB (g/L) | 108.8±18.1 | 110.0±18.9 | 0.38 | 109.2±18.5 | 110.4±19.4 | 0.51 |
| PLT (10/L) | 51.7±31.4 | 49.7±36.0 | 0.42 | 50.7±30.3 | 49.4±36.7 | 0.64 |
| TBIL (μmol/L) | 23.2±16.1 | 23.4±15.6 | 0.89 | 23.7±16.5 | 23.6±15.6 | 0.95 |
| ALT (U/L) | 31.2±16.8 | 33.0±32.5 | 0.37 | 31.3±18.0 | 31.3±16.2 | 0.99 |
| AST (U/L) | 33.6±17.3 | 33.6±22.5 | 0.99 | 32.5±15.5 | 32.3±13.1 | 0.90 |
| ALB (g/L) | 37.9±6.3 | 37.7±5.0 | 0.62 | 38.4±6.5 | 37.8±4.8 | 0.28 |
| PT (s) | 15.0±2.4 | 15.5±7.8 | 0.31 | 15.1±2.6 | 15.0±2.2 | 0.61 |
| PT-INR | 1.5±2.8 | 1.5±1.5 | 0.73 | 1.6±3.2 | 1.5±1.8 | 0.67 |
| D-dimer (mg/L) | 0.5±1.2 | 0.6±0.8 | 0.23 | 0.5±1.3 | 0.6±0.8 | 0.74 |
| Variceal hemorrhage history, n (%) | 0.06 | 1 | ||||
| Yes | 57 (16.3) | 81 (21.9) | 47 (18.1) | 47 (18.1) | ||
| No | 292 (83.7) | 289 (78.1) | 213 (81.9) | 213 (81.9) | ||
| Operation, n (%) | ||||||
| Splenectomy only | 307 (88.0) | 324 (87.6) | 0.87 | 227 (87.3) | 229 (88.1) | 0.79 |
| Concomitant pericardial devascularization | 42 (12.0) | 46 (12.4) | 33 (12.7) | 31 (11.9) | ||
| Operation period, n (%) | P<0.01 | 0.96 | ||||
| Early-period | 185 (53.0) | 103 (27.8) | 104 (40.0) | 98 (37.7) | ||
| Intermediate-period | 101 (28.9) | 140 (37.8) | 93 (35.8) | 106 (40.8) | ||
| Late-period | 63 (18.1) | 127 (34.3) | 63 (24.2) | 56 (21.5) | ||
| PSM – propensity score matching; HLD – hepatolenticular degeneration; HBV – hepatitis B virus; HCV – hepatitis C virus; WBC – white blood cell; RBC – red blood cell; HGB – hemoglobin; PLT – platelet; ALT – alanine aminotransferase; AST – aspartate aminotransferase; ALB – albumin; TBIL – total bilirubin; PT – prothrombin time. | ||||||