Measurement of Serum Levels of 5 Amino Acids and Dimethylamine Using Liquid Chromatography-Tandem Mass Spectrometry in Patients without Septic Associated Acute Kidney Injury and with Septic Associated Acute Kidney Injury Requiring Continuous Renal Replacement Therapy

07 September 2022 : Clinical Research

Patrycja Leśnik^1ABCDEFG*, Lidia Łysenko^2ADEG, Mariusz G. Fleszar

^3ABF, Paulina Fortuna

^3ABF, Ewa Woźnica-Niesobska

^2BCDE, Magdalena Mierzchała-Pasierb^3ABF, Jarosław Janc^1ABCDEFG

DOI: 10.12659/MSM.937784

Med Sci Monit 2022; 28:e937784

Background Material and Methods Results Discussion Conclusions References

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Table 4 Comparison of the level of amines and amino acids in the group with and without sepsis and septic shock.

	Sepsis						p-value*	Septic shock						p-value*
	Yes (n=18)			No (n=22)				Yes (n=22)			No (n=18)
	Me	Q1	Q3	Me	Q1	Q3		Me	Q1	Q3	Me	Q1	Q3
Arg [umol/L]	44.8	37.5	58.7	55.0	40.0	74.5	0.407	55.0	40.0	74.5	44.8	37.5	58.7	0.407
Orn [umol/L]	7.5	5.8	15.2	8.5	4.0	25.5	0.989	8.5	4.0	25.5	7.5	5.8	15.2	0.989
ADMA [umol/L]	0.6	0.6	0.8	0.6	0.4	0.7	0.161	0.6	0.4	0.7	0.6	0.6	0.8	0.161
SDMA [umol/L]	1.2	0.9	1.7	1.0	0.6	1.5	0.471	1.0	0.6	1.5	1.2	0.9	1.7	0.471
DMA [umol/L]	5.4	4.0	7.6	5.8	4.6	11.0	0.438	5.8	4.6	11.0	5.4	4.0	7.6	0.438
Cit [umol/L]	20.2	11.1	35.4	18.0	10.9	28.3	0.596	18.0	10.9	28.3	20.2	11.1	35.4	0.596
n – number of patients; Me – median; Q1 – lower quartile; Q3 – upper quartile; Arg – L-arginine; Orn – L-Ornithine; ADMA – asymmetric dimethylarginine; SDMA – symmetric dimethylarginine; DMA – dimethylamine; Cit – L-citrulline. ^* U Mann-Whitney test.

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