31 August 2022 : Clinical Research
Chemotherapy-Induced Peripheral Neuropathy (CIPN) in Patients Receiving 4-6 Cycles of Platinum-Based and Taxane-Based Chemotherapy: A Prospective, Single-Center Study from Kosovo
Blerim Myftiu12ABCDEFG*, Zylfije Hundozi12ACDF, Faton Sermaxhaj3ABD, Afrim Blyta1ACDF, Nexhmedin Shala12CD, Fisnik Jashari12C, Hasime Qorraj Bytyqi4CDF, Ekrem Hyseni3BC, Ilir Kurtishi3BCDOI: 10.12659/MSM.937856
Med Sci Monit 2022; 28:e937856
Table 6 Electrophysiological values comparison between platinum-only, taxane-only, and combination groups.
| Variable | None (Mean±SD) | Platinum (Mean±SD) | Taxane (Mean±SD) | Combination (Mean±SD) | Significance |
|---|---|---|---|---|---|
| Sensory median amplitude (μV) | 18.0±7.5 (N: 6) | 10.6±7.6 (N: 46) | 16.3±14.3 (N: 25) | 12.2±8.3 (N: 20) | p=0.08 |
| Sensory median velocity (m/s) | 58.4±10.3 (N: 6) | 48.3±8.3 (N: 46) | 49.5±9.4 (N: 25) | 50.3±7.1 (N: 20) | p=0.06 |
| Sensory ulnar amplitude (μV) | 9.7±3.7 (N: 7) | 6.9±5.4 (N: 51) | 12.1±12.5 (24) | 9.8±8.5 (N: 19) | p=0.07 |
| Sensory ulnar velocity (m/s) | 56.1±7.2 (N: 7) | 48.4±9.6 (N: 51) | 52.9±11.6 (N: 24) | 47.9±8.7 (N: 19) | p=0.07 |
| Sensory sural amplitude (μV) | 11.3±7.0 (N: 6) | 6.9±5.2 (N: 26) | 9.0±5.5 (N: 15) | 8.8±8.0 (N: 9) | p=0.36 |
| Sensory sural velocity (m/s) | 53.1±6.0 (N: 6) | 49.1±7.8 (N: 26) | 52.0±9.3 (N: 15) | 55.2±8.4 (N: 9) | p=0.23 |
| Motor median amplitude (mV) | 6.9±2.2 (N: 8) | 6.3±2.2 (N: 59) | 7.0±2.9 (N: 30) | 7.0±2.5 (N: 22) | p=0.43 |
| Motor median velocity (m/s) | 50.9±4.0 (N: 8) | 52.2±6.9 (N: 59) | 52.8±9.8 (N: 30) | 52.7±4.9 (N: 22) | p=0.94 |
| Motor ulnar amplitude (mV) | 8.4±3.2 (N: 8) | 6.4±1.9 (N: 59) | 7.4±2.4 (N: 30) | 6.9±2.2 (N: 22) | p<0.05 |
| Motor ulnar velocity (m/s) | 58.4±7.4 (N: 8) | 58.3±9.0 (N: 59) | 58.7±11.5 (N: 30) | 56.9±4.3 (N: 22) | p=0.90 |
| Motor tibial amplitude (mV) | 9.0±5.4 (N: 7) | 4.6±2.5 (N: 51) | 5.6±4.1 (N: 27) | 4.5±2.5 (N: 20) | p<0.05 |
| Motor tibial velocity (m/s) | 44.0±4.4 (N: 7) | 41.5±5.4 (N: 51) | 41.4±5.6 (N: 27) | 41.1±4.1 (N: 20) | p=0.63 |
| Motor peroneal amplitude (mV) | 2.4±1.3 (N: 7) | 2.7±1.8 (N: 50) | 2.9±2.1 (N: 27) | 2.5±1.3 (N: 19) | p=0.88 |
| Motor peroneal velocity (m/s) | 47.5±4.7 (N: 7) | 44.1±7.6 (N: 50) | 45.3±8.4 (N: 27) | 41.4±10.8 (N: 19) | p=0.29 |
| SD – standard deviation. | |||||