03 November 2022 : Database Analysis
Association Between Nadir Hematocrit and Severe Acute Kidney Injury After Off-Pump Coronary Artery Bypass Graft Surgery: A Retrospective Cohort Study Based on the MIMIC-IV Database
Yisen Deng12ACE, Bo Ma2DE, Xuming Wang12DE, Xueqiang Fan2BC, Qiangqiang Nie12B, Xixi Gao2B, Yuguang Yang2CE*, Peng Liu12CEDOI: 10.12659/MSM.937878
Med Sci Monit 2022; 28:e937878
Table 1 Characteristics of patients stratified by nadir hematocrit quartiles.
| Variables | Total (n=1783) | Hematocrit (%) | P | |||
|---|---|---|---|---|---|---|
| <25 | ≥25, and <28 | ≥28, and <31 | >31 | |||
| Age (years) | 67.8±9.9 | 71.0±9.7 | 68.3±9.5 | 66.2±9.5 | 64.7±9.5 | <0.001 |
| Sex, n (%) | <0.001 | |||||
| Female | 384 (21.5) | 228 (42.1) | 109 (27.3) | 40 (9.1) | 7 (1.7) | |
| Male | 1399 (78.5) | 314 (57.9) | 291 (72.8) | 400 (90.9) | 394 (98.3) | |
| Race, n (%) | 0.035 | |||||
| White | 1249 (70.1) | 361 (66.6) | 272 (68) | 317 (72) | 299 (74.6) | |
| Other | 534 (29.9) | 181 (33.4) | 128 (32) | 123 (28) | 102 (25.4) | |
| BMI (kg/m) | 30.2±5.5 | 28.6±5.3 | 29.7±5.6 | 30.7±5.1 | 32.2±5.4 | <0.001 |
| Myocardial infarction | 710 (39.8) | 229 (42.3) | 164 (41) | 165 (37.5) | 152 (37.9) | 0.366 |
| Congestive heart failure | 367 (20.6) | 135 (24.9) | 90 (22.5) | 81 (18.4) | 61 (15.2) | 0.001 |
| Peripheral vascular disease | 202 (11.3) | 83 (15.3) | 43 (10.8) | 42 (9.5) | 34 (8.5) | 0.004 |
| Cerebrovascular disease | 160 (9.0) | 59 (10.9) | 47 (11.8) | 34 (7.7) | 20 (5) | 0.002 |
| Chronic pulmonary disease | 287 (16.1) | 88 (16.2) | 73 (18.2) | 71 (16.1) | 55 (13.7) | 0.382 |
| Rheumatic disease | 51 (2.9) | 20 (3.7) | 20 (5) | 6 (1.4) | 5 (1.2) | 0.002 |
| Diabetes without complication | 626 (35.1) | 208 (38.4) | 150 (37.5) | 146 (33.2) | 122 (30.4) | 0.044 |
| Diabetes with complication | 173 (9.7) | 48 (8.9) | 51 (12.8) | 44 (10) | 30 (7.5) | 0.072 |
| Malignant cancer | 37 (2.1) | 11 (2) | 14 (3.5) | 8 (1.8) | 4 (1) | 0.092 |
| Heart rate (beats/minute) | 82.2±8.9 | 82.3±9.0 | 82.5±8.5 | 81.7±9.0 | 82.2±8.8 | 0.651 |
| Systolic BP (mm Hg) | 111.0±6.8 | 110.6±7.0 | 111.5±6.9 | 111.1±6.9 | 111.1±6.4 | 0.224 |
| Diastolic BP (mm Hg) | 57.1±6.2 | 54.8±6.2 | 56.6±5.7 | 58.0±5.9 | 59.6±5.8 | <0.001 |
| Respiratory rate (breaths/min) | 18.2±2.5 | 17.9±2.5 | 18.1±2.5 | 18.3±2.5 | 18.5±2.4 | <0.001 |
| Temperature (°C) | 37.2±0.4 | 37.2±0.4 | 37.2±0.4 | 37.3±0.4 | 37.3±0.4 | 0.020 |
| Glucose (mg/dL) | 184.0 (164.0, 209.0) | 192.0 (171.0, 218.0) | 184.0 (164.0, 209.0) | 178.5 (161.0, 205.0) | 178.0 (158.0, 204.0) | <0.001 |
| SpO2 (%) | 92.9±4.3 | 93.0±5.2 | 93.4±2.6 | 92.5±5.0 | 92.5±3.1 | 0.012 |
| WBC (10/L) | 17.9±9.6 | 17.3±6.4 | 17.3±6.1 | 18.2±14.2 | 19.2±9.5 | 0.007 |
| Platelet (10/L) | 179.9±57.0 | 176.8±64.0 | 178.6±54.5 | 179.5±55.7 | 185.9±50.1 | 0.103 |
| Hemoglobin (g/dL) | 11.5±1.5 | 10.4±1.3 | 11.0±1.2 | 11.9±1.1 | 12.9±1.1 | <0.001 |
| Anion gap (mmol/L) | 13.1±2.9 | 13.0±3.2 | 13.0±2.8 | 13.2±3.0 | 13.2±2.7 | 0.555 |
| BUN (mmol/L) | 16.6±5.6 | 16.5±6.7 | 16.5±5.5 | 16.5±5.0 | 16.8±4.4 | 0.800 |
| Bicarbonate (mg/dL) | 623.8±2.0 | 23.5±2.4 | 23.7±1.9 | 23.9±1.9 | 24.0±1.9 | 0.001 |
| Chloride (mmol/L) | 6107.8±3.1 | 108.5±3.5 | 107.8±2.9 | 107.7±3.0 | 107.1±2.7 | <0.001 |
| Sodium (mmol/L) | 138.5±2.9 | 138.5±3.3 | 138.3±2.8 | 138.6±2.8 | 138.5±2.5 | 0.578 |
| INR | 1.4 (1.3, 1.6) | 1.5 (1.4, 1.7) | 1.4 (1.3, 1.6) | 1.4 (1.3, 1.5) | 1.4 (1.3, 1.5) | <0.001 |
| PT (s) | 15.6 (14.4, 17.0) | 16.6 (15.0, 18.2) | 15.7 (14.5, 16.9) | 15.3 (14.3, 16.5) | 14.9 (13.8, 16.1) | <0.001 |
| APTT (s) | 32.0 (28.6, 40.3) | 34.3 (29.7, 44.7) | 32.1 (28.6, 39.2) | 31.1 (28.2, 37.2) | 30.7 (27.7, 37.1) | 0.001 |
| Lactate (mmol/L) | 3.0±1.6 | 3.5±2.1 | 2.9±1.3 | 2.7±1.4 | 2.7±1.1 | <0.001 |
| Potassium (mmol/L) | 5.2±0.6 | 5.1±0.6 | 5.1±0.6 | 5.2±0.5 | 5.2±0.7 | 0.152 |
| SOFA | 5.4±2.6 | 5.8±3.1 | 5.2±2.4 | 5.2±2.4 | 5.1±2.3 | <0.001 |
| SAPSII | 37.0±10.7 | 38.7±10.2 | 37.1±11.4 | 36.1±10.4 | 35.5±10.8 | <0.001 |
| Vasopressin | 114 (6.4) | 60 (11.1) | 27 (6.8) | 16 (3.6) | 11 (2.7) | <0.001 |
| Epinephrine | 340 (19.1) | 149 (27.5) | 80 (20) | 64 (14.5) | 47 (11.7) | <0.001 |
| Norepinephrine | 280 (15.7) | 124 (22.9) | 64 (16) | 53 (12) | 39 (9.7) | <0.001 |
| Phenylephrine | 1070 (60.0) | 334 (61.6) | 244 (61) | 265 (60.2) | 227 (56.6) | 0.441 |
| BMI – body mass index; BP – blood pressure; SpO2 – pulse oxygen saturation; WBC – white blood cell; BUN – blood urea nitrogen; INR – international normalized ratio; PT – prothrombin time; APTT – activated partial thromboplastin time; SOFA – sequential organ failure assessment; SAPSII – simplified acute physiology score II. | ||||||