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13 January 2023: Clinical Research

Elevated Serum Fibroblast Growth Factor 23 (FGF-23) Perseveres into a Convalescence Period After Elective Cardiac Surgery, with Receptor Activator of Nuclear Factor κB Ligand (RANKL) and Cartilage Oligomeric Matrix Protein (COMP) Being Part of the Peri-Surgical Pro-Arteriosclerotic Inflammatory Response

Da Liu 1BE , Wilson Y. Szeto 2E , Krzysztof Laudanski 3ACDE*

DOI: 10.12659/MSM.937934

Med Sci Monit 2023; 29:e937934

Table 1 Patient characteristics and surgical details.

Demographics (N=90)[n/N (%)]
Age [years±SD]64.1±12.15
Over 6067/90 (74.44%)
Sex
 Male69/90 (76.67%)
 Female21/90 (23.33%)
Race
 Black4/90 (4.44%)
 White79/90 (87.87%)
 Other/Asian/Unknown7/90 (7.69%)
Weight [kg] (mean±SD)83.7±20.06
BMI (mean±SD)27.5±5.71
Charleston Comorbidity Index [χ±SD]4.0±2.02
Acute coronary syndrome13/90 (14.44%)
Chronic heart failure14/90 (15.56%)
Peripheral vascular disease8/90 (8.89%)
Cerebrovascular accident/transient ischemic attack10/90 (11.11%)
Chronic obstructive pulmonary disorder8/90 (8.99%)
Diabetes melitus26/90 (28.89%)
Duration of anesthesia; mean±SD [min]3745±98.8
Duration of surgery; mean±SD [min]265.9±92.95
Duration of cardiopulmonary bypass; mean±SD [min]131.6±58.73
Coronary artery bypass surgery44/90 (48.89%)
Mitral valvuloplasty & replacement14/90 (15.56%)
Aortic valvuloplasty & replacement24/90 (26.67%)
Aortic aneurysm repair6/90 (6.67%)
Others3/90 (3.33%)
Estimated Blood Loss mean±SD [mL]202±270.9
Transfused Packed Red Blood Cells, mean; (IQ25; IQ75) [mL]85±236.1
Transfused Fresh Frozen Plasma, mean; (IQ25; IQ75) [mL]51±186
Ketorolac administration7/90 (7.87%)
Acetaminophen administration72/90 (79.78%)
Acetylsalicylic acid administration67/90 (74.16%)
Total opioids administration [mg]88.82±9.01
Total benzodiazepines administration [mg]3.7±1.71
APACHE score at 1 h17.4±5.85
APACHE score at 24 h9.7±4.93
APACHE score at 48 h9.5±5.31
LOS ICU8.7±43.2
LOS hospital10.7±22.3
Discharged home75/90 (83.33%)
Discharged to healthcare facility14/90 (15.56%)
Death1/90 (1.11%)
APACHE – Acute Physiology and Chronic Health Evaluation; LOS – length of stay; ICU – Intensive Care Unit.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750