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29 November 2022: Clinical Research

Sex-Related Differences in Sitagliptin Treatment in Type 2 Diabetes: Results from the PROLOGUE Trial

Xilin Wu 1ABCDEF , Shiming Zhang 1ABCEF , Yingzhu Jin 2ABC , Xun Xiao 3ABCDEF*

DOI: 10.12659/MSM.938030

Med Sci Monit 2022; 28:e938030

Table 1 Baseline characteristics of male participants.

CharacteristicSitagliptin groupConventional groupP-value
Age, years68.21±9.2268.66±9.240.670
Height, cm164.55±6.66165.06±5.500.479
Weight, kg68.89±10.6968.04±10.820.498
Body mass index, kg/m25.20±3.4925.10±3.910.834
Waist circumference, (cm)90.98±9.5289.67±9.710.267
Systolic blood pressure, mmHg130.01±16.22127.77±15.830.231
Diastolic blood pressure, mmHg73.66±10.3472.62±11.330.409
Fasting plasma glucose, mmol/l141.75±44.04135.86±34.480.210
Serum creatinine, μmol/l0.93±0.220.94±0.250.649
Estimated glomerular filtration rate, ml/min/1.73 m66.43±16.4765.91±16.650.786
Hypertension, N (%)121 (82.88%)116 (76.82%)0.194
Dyslipidemia, N (%)105 (71.92%)99 (65.56%)0.238
Cerebral infarction, N (%)11 (7.53%)17 (11.26%)0.272
Cerebral hemorrhage, N (%)2 (1.37%)1 (0.66%)0.542
Myocardial infarction, N (%)39 (26.71%)49 (32.45%)0.279
Arrhythmia, N (%)20 (13.70%)25 (16.56%)0.492
Chronic heart failure, N (%)12 (8.22%)19 (12.58%)0.219
Percutaneous coronary intervention, N (%)45 (30.82%)51 (33.77%)0.586
Coronary artery bypass grafting, N (%)15 (10.27%)15 (9.93%)0.923

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750