29 November 2022: Clinical Research
Sex-Related Differences in Sitagliptin Treatment in Type 2 Diabetes: Results from the PROLOGUE Trial
Xilin Wu 1ABCDEF , Shiming Zhang 1ABCEF , Yingzhu Jin 2ABC , Xun Xiao 3ABCDEF*DOI: 10.12659/MSM.938030
Med Sci Monit 2022; 28:e938030
Table 3 Comparison of atherosclerotic parameters at baseline, 12 months, and 24 months in male participants.
| Variables | Time point | Sitagliptin group | Conventional group | P-value |
|---|---|---|---|---|
| N | 146 | 151 | ||
| Mean IMT in the right CCA, mm | At baseline | 0.82±0.19 | 0.83±0.22 | 0.567 |
| Mean IMT in the left CCA, mm | At baseline | 0.84±0.20 | 0.87±0.26 | 0.272 |
| Mean IMT in the right CCA, mm | 12 months | 0.82±0.19 | 0.84±0.21 | 0.666 |
| Mean IMT in the left CCA, mm | 12 months | 0.85±0.21 | 0.84±0.20 | 0.627 |
| Mean IMT in the right CCA, mm | 24 months | 0.84±0.21 | 0.84±0.24 | 0.881 |
| Mean IMT in the left CCA, mm | 24 months | 0.82±0.18 | 0.86±0.23 | 0.149 |
| Mean IMT in the right bulb, mm | At baseline | 1.08±0.53 | 1.17±0.54 | 0.214 |
| Mean IMT in the left bulb, mm | At baseline | 1.11±0.46 | 1.13±0.48 | 0.667 |
| Mean IMT in the right bulb, mm | 12 months | 1.13±0.52 | 1.20±0.61 | 0.382 |
| Mean IMT in the left bulb, mm | 12 months | 1.19±0.58 | 1.20±0.52 | 0.856 |
| Mean IMT in the right bulb, mm | 24 months | 1.11±0.54 | 1.15±0.56 | 0.607 |
| Mean IMT in the left bulb, mm | 24 months | 1.21±0.66 | 1.15±0.45 | 0.442 |
| Mean IMT in the right ICA, mm | At baseline | 0.87±0.49 | 0.81±0.36 | 0.276 |
| Mean IMT in the left ICA, mm | At baseline | 0.78±0.30 | 0.83±0.42 | 0.259 |
| Mean IMT in the right ICA, mm | 12 months | 0.84±0.41 | 1.02±0.67 | 0.013 |
| Mean IMT in the left ICA, mm | 12 months | 0.86±0.43 | 0.88±0.48 | 0.858 |
| Mean IMT in the right ICA, mm | 24 months | 0.80±0.38 | 0.91±0.57 | 0.107 |
| Mean IMT in the left ICA, mm | 24 months | 0.74±0.35 | 0.79±0.42 | 0.390 |
| Max IMT in the right CCA, mm | At baseline | 1.04±0.25 | 1.08±0.28 | 0.223 |
| Max IMT in the left CCA, mm | At baseline | 1.07±0.28 | 1.13±0.37 | 0.105 |
| Max IMT in the right CCA, mm | 12 months | 1.03±0.26 | 1.07±0.27 | 0.265 |
| Max IMT in the left CCA, mm | 12 months | 1.08±0.28 | 1.06±0.28 | 0.570 |
| Max IMT in the right CCA, mm | 24 months | 1.05±0.27 | 1.07±0.29 | 0.577 |
| Max IMT in the left CCA, mm | 24 months | 1.06±0.25 | 1.09±0.32 | 0.440 |
| Max IMT in the right bulb, mm | At baseline | 1.53±0.73 | 1.63±0.77 | 0.296 |
| Max IMT in the left bulb, mm | At baseline | 1.59±0.69 | 1.66±0.78 | 0.450 |
| Max IMT in the right bulb, mm | 12 months | 1.56±0.72 | 1.64±0.81 | 0.459 |
| Max IMT in the left bulb, mm | 12 months | 1.63±0.80 | 1.63±0.70 | 0.976 |
| Max IMT in the right bulb, mm | 24 months | 1.60±0.73 | 1.61±0.77 | 0.927 |
| Max IMT in the left bulb, mm | 24 months | 1.71±0.84 | 1.66±0.63 | 0.568 |
| Max IMT in the right ICA, mm | At baseline | 1.16±0.60 | 1.11±0.53 | 0.523 |
| Max IMT in the left ICA, mm | At baseline | 1.05±0.41 | 1.12±0.58 | 0.259 |
| Max IMT in the right ICA, mm | 12 months | 1.14±0.59 | 1.39±0.88 | 0.016 |
| Max IMT in the left ICA, mm | 12 months | 1.18±0.61 | 1.23±0.74 | 0.602 |
| Max IMT in the right ICA, mm | 24 months | 1.09±0.52 | 1.28±0.77 | 0.049 |
| Max IMT in the left ICA, mm | 24 months | 1.01±0.45 | 1.10±0.57 | 0.221 |
| Plaque area, mm2 | At baseline | 11.46±6.14 | 12.85±10.59 | 0.294 |
| Plaque gray scale median | At baseline | 49.94±18.95 | 52.75±23.45 | 0.379 |
| Plaque area, mm | 12 months | 12.72±6.00 | 12.67±5.41 | 0.968 |
| Plaque area, mm | 24 months | 12.68±6.45 | 11.32±5.52 | 0.189 |
| Plaque gray scale median | 12 months | 59.45±31.73 | 52.18±18.87 | 0.312 |
| Plaque gray scale median | 24 months | 52.15±27.56 | 53.26±19.64 | 0.287 |