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29 November 2022: Clinical Research

Sex-Related Differences in Sitagliptin Treatment in Type 2 Diabetes: Results from the PROLOGUE Trial

Xilin Wu 1ABCDEF , Shiming Zhang 1ABCEF , Yingzhu Jin 2ABC , Xun Xiao 3ABCDEF*

DOI: 10.12659/MSM.938030

Med Sci Monit 2022; 28:e938030

Table 5 Comparison of blood lipid, blood glucose, and other indexes in male participants at 24 months.

VariablesTime pointSitagliptin groupConventional groupP-value
Weight (kg)24 months68.37±10.5968.46±11.410.947
Waist circumference (cm)24 months90.24±10.0190.76±10.770.737
Systolic blood pressure (mmHg)24 months130.05±16.23128.87±16.790.567
Diastolic blood pressure (mmHg)24 months74.07±11.2772.75±10.190.323
Pulse rate (bpm)24 months72.11±12.8370.08±11.070.188
HbA1c (%)24 months6.58±0.616.67±0.630.260
Fasting plasma glucose (mg/dL)24 months132.81±38.27130.58±35.520.640
1,5-anhydroglucitol,1,4-anhydro-D-glucitol (μg/mL)24 months16.22±8.7916.34±8.610.920
High molecular weight adiponectin (μg/mL)24 months3.59±3.795.08±4.770.012
Lactic dehydrogenase (U/L)24 months195.60±39.23209.07±87.720.126
High-density lipoprotein cholesterol (mg/dL)24 months49.59±13.3551.21±14.550.360
Triglyceride (mg/dL)24 months151.25±89.20132.45±75.070.071
Small dense low-density lipoprotein cholesterol (mg/dL)24 months35.33±17.1037.24±20.620.462
Remnant-like particle cholesterol (mg/dL)24 months5.10±3.905.44±5.030.586
Malondialdehyde-modified low-density lipoprotein (U/l)24 months121.44±36.31120.69±41.670.888
Aspartate aminotransferase (U/l)24 months26.26±14.4027.42±16.700.554
Alanine aminotransferase (U/l)24 months25.08±16.2425.27±16.580.924
Blood urea nitrogen (mg/dL)24 months16.90±5.3918.41±6.900.055
Serum creatinine (mg/dL)24 months0.98±0.310.98±0.300.885
Estimated glomerular filtration rate (ml/min/1.73 m)24 months63.88±17.5563.65±17.600.915
Cystatin C (mg/dL)24 months1.07±0.321.07±0.340.954
Urinary albumin/creatinine ratio (mg/gCre)24 months15.00 (6.15–38.75)17.00 (7.90–24.80)0.943
Uric acid (μmol/l)24 months6.07±1.206.08±1.230.949

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750