29 November 2022: Clinical Research
Sex-Related Differences in Sitagliptin Treatment in Type 2 Diabetes: Results from the PROLOGUE Trial
Xilin Wu 1ABCDEF , Shiming Zhang 1ABCEF , Yingzhu Jin 2ABC , Xun Xiao 3ABCDEF*DOI: 10.12659/MSM.938030
Med Sci Monit 2022; 28:e938030
Table 5 Comparison of blood lipid, blood glucose, and other indexes in male participants at 24 months.
| Variables | Time point | Sitagliptin group | Conventional group | P-value |
|---|---|---|---|---|
| N | 146 | 151 | ||
| Weight (kg) | 24 months | 68.37±10.59 | 68.46±11.41 | 0.947 |
| Waist circumference (cm) | 24 months | 90.24±10.01 | 90.76±10.77 | 0.737 |
| Systolic blood pressure (mmHg) | 24 months | 130.05±16.23 | 128.87±16.79 | 0.567 |
| Diastolic blood pressure (mmHg) | 24 months | 74.07±11.27 | 72.75±10.19 | 0.323 |
| Pulse rate (bpm) | 24 months | 72.11±12.83 | 70.08±11.07 | 0.188 |
| HbA1c (%) | 24 months | 6.58±0.61 | 6.67±0.63 | 0.260 |
| Fasting plasma glucose (mg/dL) | 24 months | 132.81±38.27 | 130.58±35.52 | 0.640 |
| 1,5-anhydroglucitol,1,4-anhydro-D-glucitol (μg/mL) | 24 months | 16.22±8.79 | 16.34±8.61 | 0.920 |
| High molecular weight adiponectin (μg/mL) | 24 months | 3.59±3.79 | 5.08±4.77 | 0.012 |
| Lactic dehydrogenase (U/L) | 24 months | 195.60±39.23 | 209.07±87.72 | 0.126 |
| High-density lipoprotein cholesterol (mg/dL) | 24 months | 49.59±13.35 | 51.21±14.55 | 0.360 |
| Triglyceride (mg/dL) | 24 months | 151.25±89.20 | 132.45±75.07 | 0.071 |
| Small dense low-density lipoprotein cholesterol (mg/dL) | 24 months | 35.33±17.10 | 37.24±20.62 | 0.462 |
| Remnant-like particle cholesterol (mg/dL) | 24 months | 5.10±3.90 | 5.44±5.03 | 0.586 |
| Malondialdehyde-modified low-density lipoprotein (U/l) | 24 months | 121.44±36.31 | 120.69±41.67 | 0.888 |
| Aspartate aminotransferase (U/l) | 24 months | 26.26±14.40 | 27.42±16.70 | 0.554 |
| Alanine aminotransferase (U/l) | 24 months | 25.08±16.24 | 25.27±16.58 | 0.924 |
| Blood urea nitrogen (mg/dL) | 24 months | 16.90±5.39 | 18.41±6.90 | 0.055 |
| Serum creatinine (mg/dL) | 24 months | 0.98±0.31 | 0.98±0.30 | 0.885 |
| Estimated glomerular filtration rate (ml/min/1.73 m) | 24 months | 63.88±17.55 | 63.65±17.60 | 0.915 |
| Cystatin C (mg/dL) | 24 months | 1.07±0.32 | 1.07±0.34 | 0.954 |
| Urinary albumin/creatinine ratio (mg/gCre) | 24 months | 15.00 (6.15–38.75) | 17.00 (7.90–24.80) | 0.943 |
| Uric acid (μmol/l) | 24 months | 6.07±1.20 | 6.08±1.23 | 0.949 |