29 November 2022: Clinical Research
Sex-Related Differences in Sitagliptin Treatment in Type 2 Diabetes: Results from the PROLOGUE Trial
Xilin Wu 1ABCDEF , Shiming Zhang 1ABCEF , Yingzhu Jin 2ABC , Xun Xiao 3ABCDEF*DOI: 10.12659/MSM.938030
Med Sci Monit 2022; 28:e938030
Table 6 Comparison of blood lipid, blood glucose, and other indexes in female participants at 24 months.
| Variables | Time point | Sitagliptin group | Conventional group | P-value |
|---|---|---|---|---|
| N | 76 | 69 | ||
| Weight (kg) | 24 months | 57.55±14.19 | 55.71±10.48 | 0.457 |
| Waist circumference (cm) | 24 months | 90.26±12.50 | 86.37±10.48 | 0.163 |
| Systolic blood pressure (mmHg) | 24 months | 129.39±15.27 | 131.53±20.70 | 0.510 |
| Diastolic blood pressure (mmHg) | 24 months | 71.77±12.22 | 70.51±11.97 | 0.560 |
| Pulse rate (bpm) | 24 months | 72.42±11.21 | 72.80±11.05 | 0.857 |
| HbA1c (%) | 24 months | 6.52±0.50 | 6.83±0.82 | 0.010 |
| Fasting plasma glucose (mg/dL) | 24 months | 123.68±29.32 | 128.19±42.40 | 0.505 |
| 1,5-anhydroglucitol,1,4-anhydro-D-glucitol (μg/mL) | 24 months | 16.95±8.80 | 14.52±7.94 | 0.135 |
| High molecular weight adiponectin (μg/mL) | 24 months | 5.40±3.43 | 6.09±5.45 | 0.428 |
| Lactic dehydrogenase (U/L) | 24 months | 202.46±42.14 | 215.97±37.76 | 0.078 |
| High-density lipoprotein cholesterol (mg/dL) | 24 months | 56.67±12.66 | 58.30±15.78 | 0.531 |
| Triglyceride (mg/dL) | 24 months | 114.25±51.09 | 130.89±70.05 | 0.135 |
| Small dense low-density lipoprotein cholesterol (mg/dL) | 24 months | 30.41±16.28 | 35.05±18.98 | 0.174 |
| Remnant-like particle cholesterol (mg/dL) | 24 months | 4.27±2.34 | 4.81±3.04 | 0.305 |
| Malondialdehyde-modified low-density lipoprotein (U/l) | 24 months | 109.10±35.20 | 117.49±38.43 | 0.237 |
| Aspartate aminotransferase (U/l) | 24 months | 22.92±5.78 | 24.73±10.26 | 0.225 |
| Alanine aminotransferase (U/l) | 24 months | 18.53±6.90 | 21.68±14.37 | 0.117 |
| Blood urea nitrogen (mg/dL) | 24 months | 17.79±5.54 | 18.06±8.04 | 0.826 |
| Serum creatinine (mg/dL) | 24 months | 0.72±0.22 | 0.71±0.21 | 0.720 |
| Estimated glomerular filtration rate (ml/min/1.73 m) | 24 months | 65.53±18.99 | 67.02±20.38 | 0.675 |
| Cystatin C (mg/L) | 24 months | 1.09±0.30 | 0.98±0.23 | 0.120 |
| Urinary albumin/creatinine ratio (mg/gCre) | 24 months | 18.05(11.03–29.60) | 18.10 (10.68–92.13) | 0.441 |
| Uric acid (μmol/l) | 24 months | 5.28±1.49 | 5.11±1.69 | 0.577 |