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29 November 2022: Clinical Research

Sex-Related Differences in Sitagliptin Treatment in Type 2 Diabetes: Results from the PROLOGUE Trial

Xilin Wu 1ABCDEF , Shiming Zhang 1ABCEF , Yingzhu Jin 2ABC , Xun Xiao 3ABCDEF*

DOI: 10.12659/MSM.938030

Med Sci Monit 2022; 28:e938030

Table 6 Comparison of blood lipid, blood glucose, and other indexes in female participants at 24 months.

VariablesTime pointSitagliptin groupConventional groupP-value
Weight (kg)24 months57.55±14.1955.71±10.480.457
Waist circumference (cm)24 months90.26±12.5086.37±10.480.163
Systolic blood pressure (mmHg)24 months129.39±15.27131.53±20.700.510
Diastolic blood pressure (mmHg)24 months71.77±12.2270.51±11.970.560
Pulse rate (bpm)24 months72.42±11.2172.80±11.050.857
HbA1c (%)24 months6.52±0.506.83±0.820.010
Fasting plasma glucose (mg/dL)24 months123.68±29.32128.19±42.400.505
1,5-anhydroglucitol,1,4-anhydro-D-glucitol (μg/mL)24 months16.95±8.8014.52±7.940.135
High molecular weight adiponectin (μg/mL)24 months5.40±3.436.09±5.450.428
Lactic dehydrogenase (U/L)24 months202.46±42.14215.97±37.760.078
High-density lipoprotein cholesterol (mg/dL)24 months56.67±12.6658.30±15.780.531
Triglyceride (mg/dL)24 months114.25±51.09130.89±70.050.135
Small dense low-density lipoprotein cholesterol (mg/dL)24 months30.41±16.2835.05±18.980.174
Remnant-like particle cholesterol (mg/dL)24 months4.27±2.344.81±3.040.305
Malondialdehyde-modified low-density lipoprotein (U/l)24 months109.10±35.20117.49±38.430.237
Aspartate aminotransferase (U/l)24 months22.92±5.7824.73±10.260.225
Alanine aminotransferase (U/l)24 months18.53±6.9021.68±14.370.117
Blood urea nitrogen (mg/dL)24 months17.79±5.5418.06±8.040.826
Serum creatinine (mg/dL)24 months0.72±0.220.71±0.210.720
Estimated glomerular filtration rate (ml/min/1.73 m)24 months65.53±18.9967.02±20.380.675
Cystatin C (mg/L)24 months1.09±0.300.98±0.230.120
Urinary albumin/creatinine ratio (mg/gCre)24 months18.05(11.03–29.60)18.10 (10.68–92.13)0.441
Uric acid (μmol/l)24 months5.28±1.495.11±1.690.577

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750