Suppression of Tumorigenicity 2 Pro-Inflammatory Biomarker Linking Diabetes Mellitus and Periodontitis: A Pilot Study

Paladugu Devi Navya; Gurumoorthy Kaarthikeyan; Selva Raj J.; Ahmed Alamoudi; Maha A. Bahammam; Bassam Zidane; Hammam Ahmed Bahammam; Sarah Ahmed Bahammam; Ali Abdel-Halim Abdel-Azim Hassan; Mona Awad Kamil; Shilpa Bhandi; A. Thirumal Raj; Shankargouda Patil

doi:10.12659/MSM.938218

15 November 2022 : Clinical Research

Suppression of Tumorigenicity 2 Pro-Inflammatory Biomarker Linking Diabetes Mellitus and Periodontitis: A Pilot Study

Paladugu Devi Navya^1CDF*, Gurumoorthy Kaarthikeyan^1CEF, Selva Raj J.^2BCDE, Ahmed Alamoudi^3AEF, Maha A. Bahammam^45CEF, Bassam Zidane^6BDE, Hammam Ahmed Bahammam

^7BDF, Sarah Ahmed Bahammam^8CEF, Ali Abdel-Halim Abdel-Azim Hassan^9CDE, Mona Awad Kamil^10BDE, Shilpa Bhandi^1112BEF, A. Thirumal Raj

^13CEF, Shankargouda Patil^1415ACE

DOI: 10.12659/MSM.938218

Med Sci Monit 2022; 28:e938218

Authors information Article notes Copyright and License information

¹Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
²Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
³Department of Oral Biology, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
⁴Department of Periodontology, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
⁵Executive Presidency of Academic Affairs, Saudi Commission for Health Specialties, Riyadh, Saudi Arabia
⁶Department of Restorative Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
⁷Department of Pediatric Dentistry, College of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
⁸Department of Pediatric Dentistry and Orthodontics, College of Dentistry, Taibah University, Medina, Saudi Arabia
⁹Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia
¹⁰Department of Preventive Dental Science, College of Dentistry, Jazan University, Jazan, Saudi Arabia
¹¹ College of Dental Medicine, Roseman University of Health Sciences, Jordan, USA
¹²Department of Cariology, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
¹³Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India
¹⁴Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India

^*Corresponding Author: Paladugu Navya, e-mail: [email protected]
^*Corresponding Author: Shankargouda Patil, e-mail: [email protected]

^AStudy design/planning
^BData collection/entry
^CData analysis/statistics
^DData interpretation
^EPreparation of manuscript
^FLiterature analysis/search

Background Material and Methods Results Discussion Conclusions References

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Table 1 Descriptive statistics of baseline parameters in the study population.

Group	Sex (male: female)	Age (years; mean±SD)	Gingival index (mean±SD)	Probing depth (mm; mean±SD)	Clinical attachment loss (mm; mean±SD)	Gingival crevicular fluid (pg/mL; mean±SD)
Group 1	5: 5	23.60±0.788	0	2.53±0.808	0	66.34±0.109
Group 2	5: 3	32.12±5.12	2.09±0.55	2.54±0.98	7±2.234	64.22±0.89
Group 3	7: 5	35.66±8.69	2.76±0.344	6.54±1.89	8±2.267	103.66±1.08
value	Not applicable	Not applicable	<0.0012	<0.001	<0.0018	0.001±0.02
^*

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Suppression of Tumorigenicity 2 Pro-Inflammatory Biomarker Linking Diabetes Mellitus and Periodontitis: A Pilot Study

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