Suppression of Tumorigenicity 2 Pro-Inflammatory Biomarker Linking Diabetes Mellitus and Periodontitis: A Pilot Study

Paladugu Devi Navya; Gurumoorthy Kaarthikeyan; Selva Raj J.; Ahmed Alamoudi; Maha A. Bahammam; Bassam Zidane; Hammam Ahmed Bahammam; Sarah Ahmed Bahammam; Ali Abdel-Halim Abdel-Azim Hassan; Mona Awad Kamil; Shilpa Bhandi; A. Thirumal Raj; Shankargouda Patil

doi:10.12659/MSM.938218

15 November 2022 : Clinical Research

Suppression of Tumorigenicity 2 Pro-Inflammatory Biomarker Linking Diabetes Mellitus and Periodontitis: A Pilot Study

Paladugu Devi Navya^1CDF*, Gurumoorthy Kaarthikeyan^1CEF, Selva Raj J.^2BCDE, Ahmed Alamoudi^3AEF, Maha A. Bahammam^45CEF, Bassam Zidane^6BDE, Hammam Ahmed Bahammam

^7BDF, Sarah Ahmed Bahammam^8CEF, Ali Abdel-Halim Abdel-Azim Hassan^9CDE, Mona Awad Kamil^10BDE, Shilpa Bhandi^1112BEF, A. Thirumal Raj

^13CEF, Shankargouda Patil^1415ACE

DOI: 10.12659/MSM.938218

Med Sci Monit 2022; 28:e938218

Authors information Article notes Copyright and License information

¹Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
²Department of Biochemistry, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
³Department of Oral Biology, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
⁴Department of Periodontology, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
⁵Executive Presidency of Academic Affairs, Saudi Commission for Health Specialties, Riyadh, Saudi Arabia
⁶Department of Restorative Dentistry, Faculty of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
⁷Department of Pediatric Dentistry, College of Dentistry, King Abdulaziz University, Jeddah, Saudi Arabia
⁸Department of Pediatric Dentistry and Orthodontics, College of Dentistry, Taibah University, Medina, Saudi Arabia
⁹Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia
¹⁰Department of Preventive Dental Science, College of Dentistry, Jazan University, Jazan, Saudi Arabia
¹¹ College of Dental Medicine, Roseman University of Health Sciences, Jordan, USA
¹²Department of Cariology, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
¹³Department of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, India
¹⁴Centre of Molecular Medicine and Diagnostics (COMManD), Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India

^*Corresponding Author: Paladugu Navya, e-mail: [email protected]
^*Corresponding Author: Shankargouda Patil, e-mail: [email protected]

^AStudy design/planning
^BData collection/entry
^CData analysis/statistics
^DData interpretation
^EPreparation of manuscript
^FLiterature analysis/search

Background Material and Methods Results Discussion Conclusions References

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Table 4 Multiple comparisons using post hoc tests.

Dependent variable ST2	Group (I)	Group (J)	Mean difference (I-J)	Std error	Sig.	95% Confidence Lower bound	Interval Upper bound

Tukey test	Healthy	P	−200.916^*	31.19615	.000	−278.2647	−123.5681
	Healthy	P+DM	−303.559^*	32.09114	.000	−383.1271	−223.9925

	Periodontitis	healthy	200.916^*	31.19615	.000	123.5681	278.2647
	Periodontitis	P+DM	−102.643^*	32.80524	.011	−183.9813	−21.3055

	Periodontitis+ DM	Healthy	303.559^*	32.09114	.000	223.9925	383.1271
	Periodontitis+ DM	periodontitis	102.643^*	32.80524	.011	21.3055	183.9813

Dunnett 2-sided test	Periodontitis	Healthy	200.916^*	31.19615	.000	127.9740	273.8589

	Periodontitis+ DM	Healthy	303.559^*	32.09114	.000	228.5247	378.5949
^* The mean difference is significant at the 0.05 level. ^b Dunnett-test treats 1 group as a control and compares all other groups against it. DM – diabetes mellitus.

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Suppression of Tumorigenicity 2 Pro-Inflammatory Biomarker Linking Diabetes Mellitus and Periodontitis: A Pilot Study

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