12 December 2022 : Clinical Research
Preoperative Biologics Exposure Predisposes Ulcerative Colitis Patients to a Distinct Delayed Postoperative Ileus Syndrome After Colectomy
Zhenyu Yuan1ABCEF, Liying Cui1ACD, Suting Liu1BCD, Wenhao Zhang1AEF, Qing Ji1ADE*DOI: 10.12659/MSM.938412
Med Sci Monit 2022; 28:e938412
Table 1 Characteristics of the enrolled patients (n=263).
| Characteristics | |
|---|---|
| Age at surgery (y) | 43.2±13.7 |
| Gender (Male), n (%) | 145 (55.1) |
| Body mass index (kg/m) | 19.1±2.9 |
| Disease duration (m) | 33 (1–186) |
| Disease subtype (E2: E3), n (%) | 121: 142 (45: 54) |
| Previous abdominal surgery, n (%) | 13 (4.9) |
| Preoperative medication, n (%) | |
| 5-ASA | 98 (37.3) |
| Immunomodulators | 35 (13.3) |
| Steroids | 183 (69.6) |
| Biologics | 65 (24.7) |
| Sessions/courses of biologics | 3 (1–13) |
| Current or prior Smoking, n (%) | 39 (12.2) |
| Indications of surgery (fulminant disease/treatment failure/neoplasia) | 49/208/6 |
| Emergent surgery, n (%) | 39 (14.8) |
| Laparoscopic approach, n (%) | 219 (83.3) |
| Operation type, n (%) | |
| Total proctocolectomy and pouch | 196 (74.5) |
| Subtotal colectomy | 67 (25.5) |
| Intraoperative blood loss (mL) | 100 (30–200) |
| Operative time (min) | 253.8±58.0 |
| Infectious complications, n (%) | 43 (16.3) |
| Postoperative length of stay (d) | 12 (3–42) |
| Prolonged POI, n (%) | 31 (11.8) |
| Delayed POI, n (%) | 26 (9.9) |