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12 December 2022: Clinical Research

Preoperative Biologics Exposure Predisposes Ulcerative Colitis Patients to a Distinct Delayed Postoperative Ileus Syndrome After Colectomy

Zhenyu Yuan ABCEF , Liying Cui ACD , Suting Liu BCD , Wenhao Zhang AEF , Qing Ji ADE*

DOI: 10.12659/MSM.938412

Med Sci Monit 2022; 28:e938412

Table 2 Univariate and multivariate analysis of risk factors associated with DPOI.

Univariate analysisMultivariate analysis
DPOI (N=26)Non-DPOI (N=237)pOdds ratio (95% CI)p
Age at surgery (y)47.8±11.542.4±13.90.0591.028 (0.996–1.062)0.089
Gender (Male)13 (50.0)132 (55.7)0.579
Body mass index (kg/m)19.8±3.219.0±2.90.1711.112 (0.960–1.287)0.155
Disease duration (m)35.0 (2–120)32.0 (1–186)0.862
Disease subtype (E2: E3)9: 17112: 1250.371
Previous abdominal surgery3 (11.5)10 (4.2)0.1023.835 (0.858–17.131)0.078
Preoperative medication
 5-ASA6 (23.1)92 (38.8)0.1150.492 (0.183–1.323)0.160
 Immunomodulators1 (3.8)34 (14.3)0.1350.158 (0.020–1.266)0.082
 Steroids16 (61.5)167 (70.5)0.348
 Biologics12 (46.2)53 (22.4)0.0083.100 (1.261–7.619)0.014
 Anti-TNF5 (26.3)31 (14.4)0.184*
 Vedolizumab2 (12.5)5 (2.6)0.095*
 Anti-TNF+Vedolizumab5 (26.3)17 (8.5)0.028*
Sessions of biologics4 (1–13)3 (1–10)0.024
Smoking history6 (23.1)33 (13.9)0.213
Indications of surgery (fulminant disease/treatment failure/neoplasia)5/19/044/189/60.193**
Emergent surgery3 (11.5)36 (15.2)0.619*
Laparoscopic approach24 (92.3)195 (82.2)0.1952.478 (0.695–8.833)0.162
TPC: STC21: 5175: 620.441
Intraoperative blood loss (mL)90 (50–150)120 (30–200)0.324
Operative time (min)241.2±58.2255.2±58.00.265
Infectious complications4 (15.4)39 (16.5)0.889*
Postoperative length of stay (d)11 (3–24)12 (4–42)0.241
Prolonged POI5 (19.2)26 (11.0)0.215*
* Fisher’s exact test;
** ANOVA test;
TPC – total proctocolectomy with loop ileostomy; STC – subtotal colectomy with end ileostomy.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750