12 December 2022 : Clinical Research
Preoperative Biologics Exposure Predisposes Ulcerative Colitis Patients to a Distinct Delayed Postoperative Ileus Syndrome After Colectomy
Zhenyu Yuan1ABCEF, Liying Cui1ACD, Suting Liu1BCD, Wenhao Zhang1AEF, Qing Ji1ADE*DOI: 10.12659/MSM.938412
Med Sci Monit 2022; 28:e938412
Table 2 Univariate and multivariate analysis of risk factors associated with DPOI.
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| DPOI (N=26) | Non-DPOI (N=237) | p | Odds ratio (95% CI) | p | |
| Age at surgery (y) | 47.8±11.5 | 42.4±13.9 | 0.059 | 1.028 (0.996–1.062) | 0.089 |
| Gender (Male) | 13 (50.0) | 132 (55.7) | 0.579 | ||
| Body mass index (kg/m) | 19.8±3.2 | 19.0±2.9 | 0.171 | 1.112 (0.960–1.287) | 0.155 |
| Disease duration (m) | 35.0 (2–120) | 32.0 (1–186) | 0.862 | ||
| Disease subtype (E2: E3) | 9: 17 | 112: 125 | 0.371 | ||
| Previous abdominal surgery | 3 (11.5) | 10 (4.2) | 0.102 | 3.835 (0.858–17.131) | 0.078 |
| Preoperative medication | |||||
| 5-ASA | 6 (23.1) | 92 (38.8) | 0.115 | 0.492 (0.183–1.323) | 0.160 |
| Immunomodulators | 1 (3.8) | 34 (14.3) | 0.135 | 0.158 (0.020–1.266) | 0.082 |
| Steroids | 16 (61.5) | 167 (70.5) | 0.348 | ||
| Biologics | 12 (46.2) | 53 (22.4) | 0.008 | 3.100 (1.261–7.619) | 0.014 |
| Anti-TNF | 5 (26.3) | 31 (14.4) | 0.184* | ||
| Vedolizumab | 2 (12.5) | 5 (2.6) | 0.095* | ||
| Anti-TNF+Vedolizumab | 5 (26.3) | 17 (8.5) | 0.028* | ||
| Sessions of biologics | 4 (1–13) | 3 (1–10) | 0.024 | ||
| Smoking history | 6 (23.1) | 33 (13.9) | 0.213 | ||
| Indications of surgery (fulminant disease/treatment failure/neoplasia) | 5/19/0 | 44/189/6 | 0.193** | ||
| Emergent surgery | 3 (11.5) | 36 (15.2) | 0.619* | ||
| Laparoscopic approach | 24 (92.3) | 195 (82.2) | 0.195 | 2.478 (0.695–8.833) | 0.162 |
| TPC: STC | 21: 5 | 175: 62 | 0.441 | ||
| Intraoperative blood loss (mL) | 90 (50–150) | 120 (30–200) | 0.324 | ||
| Operative time (min) | 241.2±58.2 | 255.2±58.0 | 0.265 | ||
| Infectious complications | 4 (15.4) | 39 (16.5) | 0.889* | ||
| Postoperative length of stay (d) | 11 (3–24) | 12 (4–42) | 0.241 | ||
| Prolonged POI | 5 (19.2) | 26 (11.0) | 0.215* | ||
| * Fisher’s exact test; ** ANOVA test; TPC – total proctocolectomy with loop ileostomy; STC – subtotal colectomy with end ileostomy. | |||||