21 November 2022 : Clinical Research
Long-Term Effect of Pancreaticoduodenectomy Combined with Revascularization for Resectable Pancreatic Carcinoma in Elderly Patients
Jiali Yang1ABCDEF, Zhengrong Xu2ABCD, Junfeng Zhang1CD, Yao Zheng1CD, Jianyou Gu1AC, Qiang Zhou1CD, Xianxing Wang1CD, Shixiang Guo1DF, Hongyu Zhang3AD, Shengkai Chen1ADG*, Huaizhi Wang1ADGDOI: 10.12659/MSM.938443
Med Sci Monit 2022; 28:e938443
Table 2 Perioperative and pathologic characteristics of the PDAC patients who underwent PDR according to age.
| Variables | Total (n=185) | Age <60 y (n=103) | 60 y ≤ Age <70 y (n=55) | Age ≥70 y (n=27) | P value |
|---|---|---|---|---|---|
| Type of PD* | 0.851 | ||||
| PPPD | 29 (15.7) | 15 (14.6) | 10 (18.2) | 4 (14.8) | |
| Whipple | 156 (83.3) | 88 (85.4) | 45 (81.8) | 23 (85.2) | |
| Vascular invasion site* | 0.755 | ||||
| PV | 23 (12.4) | 12 (11.7) | 7 (12.7) | 4 (14.8) | |
| Confluence of SMV and PV | 83 (44.9) | 48 (46.6) | 26 (47.3) | 9 (33.3) | |
| SMV | 79 (42.7) | 43 (41.7) | 22 (40.0) | 14 (51.9) | |
| Types of venous reconstruction* | 0.073 | ||||
| Interposition graft | 70 (37.8) | 44 (42.7) | 22 (40.0) | 4 (14.8) | |
| End-to-end anastomosis | 101 (54.6) | 51 (49.5) | 30 (54.5) | 20 (74.1) | |
| Primary closure | 14 (7.6) | 8 (7.8) | 3 (5.5) | 3 (11.1) | |
| Ligation of splenic vein* | 26 (14.1) | 16 (15.5) | 6 (10.9) | 4 (14.8) | 0.764 |
| Combined organ resection* | 11 (5.9) | 6 (5.8) | 2 (3.6) | 3 (11.1) | 0.386 |
| Operation duration (min)** | 460 (178–960) | 470 (245–960) | 458 (277–814) | 410 (178–640) | 0.063 |
| Operative blood loss (ml)** | 600 (200–7200) | 600 (200–7200) | 600 (200–4000) | 600 (200–1700) | 0.566 |
| Operative blood transfusion (ml)** | 400 (0–3500) | 400 (0–3500) | 300 (0–2550) | 400 (0–1200) | 0.689 |
| Postoperative hospital stay (days)** | 20 (5–164) | 21 (5–164) | 19 (8–36) | 19 (6–42) | 0.246 |
| ICU stay (days)** | 3 (1–90) | 3 (1–90) | 3 (1–25) | 3 (2–13) | 0.035 |
| Tumor size (cm)** | 3 (2.1–4.0) | 3 (2.1–4.0) | 3 (3.0–3.5) | 3.5 (2.5–4.0) | 0.588 |
| Degree of differentiation* | 0.783 | ||||
| Well | 14 (7.6) | 5 (4.9) | 3 (5.5) | 13 (48.1) | |
| Moderate | 130 (70.3) | 78 (75.7) | 39 (70.9) | 13 (48.1) | |
| Poor | 41 (22.2) | 20 (19.4) | 13 (23.6) | 8 (29.6) | |
| Pathological invasion of PV-SMV* | 38 (20.5) | 17 (16.5) | 12 (21.8) | 9 (33.3) | 0.150 |
| Neurological invasion* | 90 (48.6) | 55 (53.4) | 22 (40.0) | 13 (48.1) | 0.275 |
| Resection margin* | 0.505 | ||||
| R0 | 176 (95.1) | 98 (95.1) | 51 (92.7) | 51 (92.7) | |
| R1 | 9 (4.9) | 5 (4.9) | 4 (7.3) | 0 | |
| TNM staging* | 0.837 | ||||
| I | 105 (56.8) | 55 (53.3) | 34 (61.8) | 16 (59.3) | |
| II | 57 (30.8) | 34 (33.0) | 15 (27.3) | 8 (29.6) | |
| III | 13 (7.0) | 9 (8.7) | 2 (3.6) | 2 (7.4) | |
| IV | 10 (5.4) | 5 (4.9) | 4 (7.3) | 1 (3.7) | |
| T staging* | 0.346 | ||||
| T1 | 41 (22.1) | 22 (21.3) | 14 (25.5) | 5 (18.5) | |
| T2 | 109 (58.9) | 56 (54.3) | 33 (60.0) | 20 (74.0) | |
| T3 | 30 (16.2) | 22 (21.3) | 6 (10.9) | 2 (7.4) | |
| T4 | 5 (2.7) | 3 (2.9) | 2 (3.6) | 0 | |
| N staging* | 0.267 | ||||
| N0 | 131 (70.8) | 72 (59.9) | 42 (76.4) | 17 (63.0) | |
| N1 | 44 (23.8) | 23 (22.3) | 13 (23.6) | 8 (29.6) | |
| N2 | 10 (5.4) | 8 (7.8) | 0 | 2 (7.4) | |
| Distant metastasis* | 10 (5.4) | 5 (4.9) | 4 (7.3) | 1 (3.7) | 0.900 |
| * Results are presented as a number (percentage); ** results are presented as the median (range). | |||||