21 November 2022 : Clinical Research
Long-Term Effect of Pancreaticoduodenectomy Combined with Revascularization for Resectable Pancreatic Carcinoma in Elderly Patients
Jiali Yang1ABCDEF, Zhengrong Xu2ABCD, Junfeng Zhang1CD, Yao Zheng1CD, Jianyou Gu1AC, Qiang Zhou1CD, Xianxing Wang1CD, Shixiang Guo1DF, Hongyu Zhang3AD, Shengkai Chen1ADG*, Huaizhi Wang1ADGDOI: 10.12659/MSM.938443
Med Sci Monit 2022; 28:e938443
Table 3 Postoperative complications of stays the PDAC patients who underwent PDR according to age.
| Variables | Total (n=185) | Age <60 y (n=103) | 60 y ≤ Age <70 y (n=55) | Age ≥70 y (n=27) | P value |
|---|---|---|---|---|---|
| Clavien-Dindo classification | 114 (61.6) | 63 (61.2) | 34 (61.8) | 17 (63.0) | 0.985 |
| I | 29 (15.7) | 15 (14.6) | 11 (20.0) | 3 (11.1) | |
| II | 56 (30.3) | 35 (34.0) | 16 (29.1) | 5 (18.5) | |
| III | 12 (6.5) | 7 (6.8) | 4 (7.3) | 1 (3.7) | |
| IV | 13 (7.0) | 5 (4.9) | 1 (1.8) | 7 (25.9) | |
| V | 4 (2.2) | 1 (1.0) | 2 (3.6) | 1 (3.7) | |
| Grade of complication ≥III | 29 (15.8) | 13 (12.6) | 7 (12.7) | 9 (33.3) | 0.043 |
| Pancreatic fistula | 15 (8.1) | 9 (8.7) | 4 (7.3) | 2 (7.4) | 1.000 |
| Grade A | 7 (3.9) | 4 (3.9) | 2 (3.6) | 1 (3.7) | |
| Grade B | 3 (1.6) | 2 (1.9) | 1 (1.8) | 0 | |
| Grade C | 4 (2.2) | 3 (2.9) | 1 (1.8) | 1 (3.7) | |
| Non-pancreatic anastomotic leakage | 11 (5.9) | 9 (8.7) | 2 (3.6) | 0 | 0.227 |
| Biliary anastomotic leakage | 7 (3.8) | 6 (5.8) | 1 (1.8) | 0 | |
| Gastrointestinal anastomotic leakage | 4 (2.2) | 3 (2.9) | 1 (1.8) | 0 | |
| Lymphatic leakage | 6 (3.2) | 5 (4.8) | 0 | 1 (3.7) | 0.229 |
| Delayed gastric emptying | 21 (11.4) | 13 (12.6) | 7 (12.7) | 1 (3.7) | 0.495 |
| Grade A | 7 (3.9) | 3 (2.9) | 3 (5.5) | 1 (3.7) | |
| Grade B | 9 (4.9) | 8 (7.8) | 1 (1.8) | 0 | |
| Grade C | 5 (2.7) | 2 (1.9) | 3 (5.5) | 0 | |
| Post-pancreatectomy hemorrhage | 30 (16.2) | 17 (16.5) | 10 (18.2) | 3 (11.1) | 0.787 |
| Grade A | 10 (5.4) | 6 (5.8) | 4 (7.3) | 0 | |
| Grade B | 3 (1.6) | 1 (1.0) | 2 (3.6) | 0 | |
| Grade C | 17 (9.2) | 10 (9.7) | 4 (7.3) | 3 (11.1) | |
| Gastrointestinal hemorrhage | 22 (11.9) | 13 (12.6) | 8 (14.5) | 1 (3.7) | 0.352 |
| Intraperitoneal hemorrhage | 15 (8.1) | 9 (8.7) | 3 (5.5) | 3 (11.1) | 0.562 |
| Hepatic ischemia–reperfusion injury | 26 (14.1) | 18 (17.5) | 5 (9.1) | 3 (11.1) | 0.369 |
| Blood transfusion for non-hemorrhagic anemia | 25 (13.5) | 14 (13.6) | 7 (12.7) | 4 (14.8) | 1.000 |
| Thoracic or abdominal puncture and drainage | 13 (7.0) | 10 (9.7) | 2 (3.6) | 1 (3.7) | 0.402 |
| Organ dysfunction | 17 (9.2) | 6 (5.8) | 3 (5.5) | 8 (29.6) | 0.002 |
| MODS | 7 (3.8) | 3 (2.9) | 3 (5.5) | 1 (3.7) | |
| Single-organ dysfunction | 10 (5.4) | 3 (2.9) | 0 | 7 (25.9) | |
| Infections | 51 (27.6) | 27 (26.2) | 13 (23.6) | 11 (40.7) | 0.239 |
| Pulmonary infection | 25 (13.5) | 9 (8.7) | 6 (10.9) | 10 (37.0) | 0.002 |
| Intraperitoneal infection | 28 (15.1) | 19 (18.4) | 6 (10.9) | 3 (11.1) | 0.410 |
| Re-laparotomy | 19 (10.3) | 11 (0.7) | 5 (9.1) | 3 (11.1) | 1.000 |
| Mortality (90 d) | 15 (8.1) | 6 (5.8) | 4 (7.3) | 5 (18.5) | 0.095 |
| Results are presented as a number (percentage); MODS – multiple organ dysfunction syndromes. | |||||