25 January 2023: Clinical Research
Changes in Heparin-Binding Protein, Procalcitonin, and C-Reactive Protein Within the First 72 Hours Predict 28-Day Mortality in Patients Admitted to the Intensive Care Unit with Septic Shock
Hui Xue ABCDEFG , Feng Yu AFG*DOI: 10.12659/MSM.938538
Med Sci Monit 2023; 29:e938538
Table 3 logistic regression model for survival in patients with septic shock.
| Parameter | Univariable OR (95% CI) | P value | Multivariable OR (95% CI) | P value |
|---|---|---|---|---|
| Age | 1.00 (0.98–1.03) | 0.82 | ||
| APACHE II score | 1.39 (1.14–1.68) | 0.001 | 1.10 (0.88–1.37) | 0.410 |
| ΔSOFA decreasing values | 1.93 (1.00–3.75) | 0.051 | 1.93 (0.79–4.69) | 0.146 |
| ΔHBP decreasing levels | 9.95 (4.63–21.35) | 0.000 | 7.18 (2.91–17.69) | 0.000 |
| ΔPCT decreasing levels | 7.85 (3.74–16.49) | 0.000 | 5.17 (2.12–12.56) | 0.000 |
| ΔCRP decreasing levels | 5.83 (2.84–11.97) | 0.000 | 4.33 (1.77–10.61) | 0.001 |
| The results show univariate and multivariate logistic regression analyses of the kinetics of biomarkers and clinical scores. APACHE II – Acute Physiology and Chronic Health Evaluation; SOFA – Sequential Organ Failure Assessment; HBP – heparin-binding protein; PCT – procalcitonin; CRP – C-reactive protein; OR – odds ratio; CI – confidence interval. ΔSOFA=SOFA72H–SOFA0H; ΔHBP=HBP72H–HBP0H; ΔPCT=PCT72H–PCT0H; ΔCRP=CRP72H–CRP0H. | ||||