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30 November 2022 : Clinical Research  

Clinicopathological Features of Breast Cancer in Relation to Exposure of Cycling Reproductive Hormones: A Multicenter Retrospective Study of 14,731 Patients Diagnosed with Invasive Breast Cancer

Jiazheng Sun1BE, Jinxiang Tan1BC, Hong Zheng2B, Jun Jiang3B, Tianning Zou4BC, Hongyuan Li5BF, Guosheng Ren5BC, Dejuan Yang5AG*

DOI: 10.12659/MSM.938619

Med Sci Monit 2022; 28:e938619

Table 1 Comparsion of clinicopathologic characteristics between menarche age <14 yrs and ≥14 yrs breast cancer patients.

Tumor charactersAll patientsPremenopausal patientsPostmenopausal patients
No. of menarche age <14/≥14 (ref) patientsOdds ratio (95% CI)P-valueNo. of menarche age <14/≥14 (ref) patientsOdds ratio (95% CI)P-valueNo. of menarche age <14/≥14 (ref) patientsOdds ratio (95% CI)P-value
 No5129/79331.03283/45001.01846/34331.0
 Yes202/2921.11 (0.65, 1.92)0.7014132/1761.21 (0.57, 2.57)0.61170/1161.05 (0.44, 2.49)0.9192
 Unknown375/507257/283118/224
 Ductal carcinoma4155/67181.02654/38961.01501/28221.0
 Lobular carcinoma123/1910.59 (0.33, 1.03)0.062284/1070.51 (0.23, 1.12)0.094839/840.75 (0.33, 1.71)0.4939
 Medullary carcinoma72/1151.23 (0.32, 4.78)0.76856/771.34 (0.19, 9.54)0.770216/381.29 (0.17, 9.55)0.8044
 Mucinous carcinoma128/17674/9954/77
 Mix90/1480.39 (0.04, 3.50)0.397763/980.40 (0.04, 3.97)0.432227/500.9915
 Unknown1138/1348741/682397/702
 No3119/44081.01938/23711.01181/20371.0
 Yes14/231.35 (0.19, 9.69)0.764110/140.95 (0.06, 15.39)0.97114/92.22 (0.12, 41.56)0.5949
 Unknown2573/43011724/2574849/1727
 No3047/42541896/22861151/1968
 Yes92/1790.98 (0.55, 1.73)0.94559/1061.62 (0.73, 3.57)0.236133/730.55 (0.21, 1.43)0.2205
 Unknown2567/42991708/2567859/1732
 No1618/21531.0993/11111.0625/10421.0
 Yes1401/21020.92 (0.79, 1.08)0.3057852/11710.87 (0.71, 1.07)0.1903549/9310.96 (0.76, 1.21)0.6976
 Unknown2687/44771827/2677860/1800
 I231/3001.0140/1691.091/1311.0
 II2248/31950.92 (0.75, 1.13)0.40831387/1716861/14791.28 (0.93, 1.77)0.1351
 III760/1215469/659291/5561.07 (0.70, 1.64)0.7617
 Unknown2467/40221676/2415791/1607
 T1 (≤20 mm)1616/21901.01002/11901.0614/10001.0
 T2 (20 mm2188/33900.92 (0.62, 1.37)0.68511397/18731.01 (0.57, 1.80)0.9625791/15170.86 (0.49, 1.51)0.5916
 T3 (>50 mm)246/3870.86 (0.49, 1.51)0.6013161/2350.87 (0.40, 1.88)0.717385/1520.85 (0.36, 1.98)0.7035
 T482/16146/850.71 (0.12, 4.24)0.7039508/760.9716
 Unknown1574/26041066/1576508/1028
 N02441/35261.01557/19471.0884/15791.0
 N11151/18180.99 (0.83, 1.19)0.9484763/10620.95 (0.75, 1.21)0.6879388/7561.00 (0.76, 1.31)0.9817
 N2456/7171.09 (0.84, 1.42)0.5119294/4020.96 (0.67, 1.36)0.8002162/3151.26 (0.83, 1.91)0.2863
 N3281/4000.97 (0.69, 1.36)0.8533154/2180.68 (0.40, 1.15)0.1487127/1821.42 (0.90, 2.24)0.1316
 Unknown1377/2271904/1330473/941
 M04254/63621.02723/35731.01531/27891.0
 M143/501.86 (0.60, 5.71)0.279922/232.34 (0.37, 14.90)0.366421/272.63 (0.58, 11.96)0.2105
 Unknown1409/2420927/1363482/957
 ≤15798/10351.0494/5851.0304/4501.0
 >15, ≤20787/10951.11 (0.89, 1.38)0.3774484/5631.31 (0.97, 1.78)0.0836303/5320.92 (0.66, 1.28)0.6109
 >20, ≤301135/16521.06 (0.69, 1.62)0.8029724/8621.37 (0.75, 2.52)0.3098411/7900.73 (0.39, 1.36)0.3248
 >30886/13581.14 (0.74, 1.76)0.5599550/7611.28 (0.69, 2.37)0.4361336/5970.90 (0.47, 1.70)0.737
 Unknown2100/35921421/2188679/1404
 Negetive1979/29751.01230/15831.0749/13921.0
 Positive3487/53540.90 (0.72, 1.13)0.37262278/31340.81 (0.58, 1.13)0.22231209/22191.04 (0.75, 1.43)0.8225
 Unknown240/403164/24276/162
 Negetive2336/34621.01340/18021.0996/18401.0
 Positive3125/46731.13 (0.91, 1.40)0.27532116/29061.15 (0.84, 1.58)0.38181009/17670.97 (0.71, 1.32)0.834
 Unknown245/417166/25179/166
 Negetive2988/44501.01932/25941.01056/18561.0
 Positive1903/28291.06 (0.91, 1.24)0.45561179/14911.00 (0.81, 1.23)0.9819724/13381.17 (0.92, 1.48)0.1936
 Unknown815/1453561/874254/579
 ≤20%1487/20761.0911/10571.0576/10091.0
 >20%1321/18550.99 (0.84, 1.17)0.9147853/10010.90 (0.72, 1.12)0.3569468/8641.03 (0.81, 1.32)0.8157
 Unknown2898/48011908/2901990/1900
 Negative1210/14881.0700/7681.0510/7201.0
 Positive1749/23650.93 (0.79, 1.09)0.38741095/12670.94 (0.75, 1.17)0.5568654/10980.91 (0.71, 1.15)0.4145
 Unknown2747/48791877/2924870/1955

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750