Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

30 November 2022 : Clinical Research  

Clinicopathological Features of Breast Cancer in Relation to Exposure of Cycling Reproductive Hormones: A Multicenter Retrospective Study of 14,731 Patients Diagnosed with Invasive Breast Cancer

Jiazheng Sun1BE, Jinxiang Tan1BC, Hong Zheng2B, Jun Jiang3B, Tianning Zou4BC, Hongyuan Li5BF, Guosheng Ren5BC, Dejuan Yang5AG*

DOI: 10.12659/MSM.938619

Med Sci Monit 2022; 28:e938619

Table 3 Correlation of clinicopathologic features with longer reproductive years among luminal and HER2-overexpression breast cancer.

Tumor charactersLuminalHER2 overexpression
No. of reproductive years ≥35/<35 yrs (ref) patientsOdds ratio (95% CI)P-valueNo. of reproductive years ≥35/<35 yrs (ref) patientsOdds ratio (95% CI)P-value
 No1324/1598179/192
 Yes117/1621.20 (0.62, 2.29)0.589915/100.21 (0.01, 3.33)0.2654
 Ductal carcinoma1209/1491169/174
 Lobular carcinoma39/441.00 (0.31, 3.26)0.99880/0
 Medullary carcinoma4/52/3
 Mucinous carcinoma38/411.61 (0.51, 5.08)0.41540/2
 Mix0/00/0
 No609/83092/93
 Yes5/5>999.999 (999.999)0.98691/0
 No595/80390/88
 Yes28/380.72 (0.25, 2.10)0.55024/61.82 (0.04, 89.10)0.7642
 No320/45122/
 Yes278/4011.27 (0.85, 1.89)0.247755/0.43 (0.06, 3.27)0.4155
 I62/1035/6
 II512/6531.55 (0.94, 2.55)0.086953/705.75 (0.22, 149.94)0.2932
 III179/2261.38 (0.67, 2.83)0.380051/400.72 (0.03, 18.17)0.8387
 T1 (≤20 mm)370/46443/34
 T2 (20 mm492/6230.49 (0.18, 1.32)0.156084/910.15 (0.00, 5.73)0.304
 T3 (>50 mm)51/750.84 (0.16, 4.54)0.837615/130.60 (0.01, 53.61)0.8234
 T443/445/30.9715
 N0552/69879/81
 N1275/3400.83 (0.51, 1.35)0.446949/460.93 (0.08, 10.69)0.9506
 N2111/1580.76 (0.38, 1.52)0.442515/170.11 (0.00, 5.33)0.2605
 N372/880.57 (0.22, 1.50)0.255413/143.48 (0.06, 195.90)0.5444
 M0988/1265152/155
 M116/101.09 (0.10, 11.93)0.94704/0
 ≤15166/23818/12
 >15, ≤20166/2121.15 (0.67, 1.97)0.616625/190.23 (0.01, 10.72)0.4513
 >20, ≤30239/3262.31 (0.78, 6.83)0.129228/396.44 (0.25, 168.28)0.2633
 >30172/2402.55 (0.86, 7.56)0.092440/46
 ≤20%467/65747/51
 >20%155/1531.04 (0.51, 2.13)0.918657/450.91 (0.09, 9.26)0.9344
 Negative246/37620/24
 Positive248/3750.89 (0.60, 1.32)0.554638/441.86 (0.25, 13.98)0.5488

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750