30 November 2022: Clinical Research
Clinicopathological Features of Breast Cancer in Relation to Exposure of Cycling Reproductive Hormones: A Multicenter Retrospective Study of 14 731 Patients Diagnosed with Invasive Breast Cancer
Jiazheng Sun 1BE , Jinxiang Tan 1BC , Hong Zheng 2B , Jun Jiang 3B , Tianning Zou 4BC , Hongyuan Li 1BF , Guosheng Ren 1BC* , Dejuan Yang 1AG*DOI: 10.12659/MSM.938619
Med Sci Monit 2022; 28:e938619
Table 3 Correlation of clinicopathologic features with longer reproductive years among luminal and HER2-overexpression breast cancer.
| Tumor characters | Luminal | HER2 overexpression | ||||
|---|---|---|---|---|---|---|
| No. of reproductive years ≥35/<35 yrs (ref) patients | Odds ratio (95% CI) | P-value | No. of reproductive years ≥35/<35 yrs (ref) patients | Odds ratio (95% CI) | P-value | |
| No | 1324/1598 | 179/192 | ||||
| Yes | 117/162 | 1.20 (0.62, 2.29) | 0.5899 | 15/10 | 0.21 (0.01, 3.33) | 0.2654 |
| Ductal carcinoma | 1209/1491 | 169/174 | ||||
| Lobular carcinoma | 39/44 | 1.00 (0.31, 3.26) | 0.9988 | 0/0 | – | – |
| Medullary carcinoma | 4/5 | – | – | 2/3 | – | – |
| Mucinous carcinoma | 38/41 | 1.61 (0.51, 5.08) | 0.4154 | 0/2 | – | – |
| Mix | 0/0 | – | 0/0 | – | – | |
| No | 609/830 | 92/93 | ||||
| Yes | 5/5 | >999.999 (999.999) | 0.9869 | 1/0 | – | – |
| No | 595/803 | 90/88 | ||||
| Yes | 28/38 | 0.72 (0.25, 2.10) | 0.5502 | 4/6 | 1.82 (0.04, 89.10) | 0.7642 |
| No | 320/451 | 22/ | ||||
| Yes | 278/401 | 1.27 (0.85, 1.89) | 0.2477 | 55/ | 0.43 (0.06, 3.27) | 0.4155 |
| I | 62/103 | 5/6 | ||||
| II | 512/653 | 1.55 (0.94, 2.55) | 0.0869 | 53/70 | 5.75 (0.22, 149.94) | 0.2932 |
| III | 179/226 | 1.38 (0.67, 2.83) | 0.3800 | 51/40 | 0.72 (0.03, 18.17) | 0.8387 |
| T1 (≤20 mm) | 370/464 | 43/34 | ||||
| T2 (20 mm | 492/623 | 0.49 (0.18, 1.32) | 0.1560 | 84/91 | 0.15 (0.00, 5.73) | 0.304 |
| T3 (>50 mm) | 51/75 | 0.84 (0.16, 4.54) | 0.8376 | 15/13 | 0.60 (0.01, 53.61) | 0.8234 |
| T4 | 43/44 | 5/3 | 0.9715 | |||
| N0 | 552/698 | 79/81 | ||||
| N1 | 275/340 | 0.83 (0.51, 1.35) | 0.4469 | 49/46 | 0.93 (0.08, 10.69) | 0.9506 |
| N2 | 111/158 | 0.76 (0.38, 1.52) | 0.4425 | 15/17 | 0.11 (0.00, 5.33) | 0.2605 |
| N3 | 72/88 | 0.57 (0.22, 1.50) | 0.2554 | 13/14 | 3.48 (0.06, 195.90) | 0.5444 |
| M0 | 988/1265 | 152/155 | ||||
| M1 | 16/10 | 1.09 (0.10, 11.93) | 0.9470 | 4/0 | – | – |
| ≤15 | 166/238 | 18/12 | ||||
| >15, ≤20 | 166/212 | 1.15 (0.67, 1.97) | 0.6166 | 25/19 | 0.23 (0.01, 10.72) | 0.4513 |
| >20, ≤30 | 239/326 | 2.31 (0.78, 6.83) | 0.1292 | 28/39 | 6.44 (0.25, 168.28) | 0.2633 |
| >30 | 172/240 | 2.55 (0.86, 7.56) | 0.0924 | 40/46 | – | – |
| ≤20% | 467/657 | 47/51 | ||||
| >20% | 155/153 | 1.04 (0.51, 2.13) | 0.9186 | 57/45 | 0.91 (0.09, 9.26) | 0.9344 |
| Negative | 246/376 | 20/24 | ||||
| Positive | 248/375 | 0.89 (0.60, 1.32) | 0.5546 | 38/44 | 1.86 (0.25, 13.98) | 0.5488 |