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28 March 2023: Database Analysis

A Novel Immune-Related Signature to Predict Prognosis and Immune Infiltration of Cervical Cancer

Yun Lin 1ABCDE , Rendong Zhang 2BCD , Hongchao Pan 1CDG , Yaochen Li 1AEG*

DOI: 10.12659/MSM.938660

Med Sci Monit 2023; 29:e938660

Authors information Article notes Copyright and License information

Supplementary Table 1 Univariate Cox regression analyses for 298 genes and overall survival of cervical cancer.

GenesTotal (N)Hazard ratio (95% CI)p value
SEMA3F3061.121 (0.706–1.780)0.629
IL323060.767 (0.482–1.221)0.263
TYMP3061.317 (0.826–2.101)0.248
CDH13061.237 (0.777–1.970)0.369
ADRB13060.585 (0.366–0.936)
IL17RB3060.685 (0.427–1.097)0.115
FGFR33060.605 (0.378–0.969)
GAL3061.448 (0.908–2.310)0.120
TFRC3061.697 (1.056–2.726)
IL12RB23060.808 (0.506–1.288)0.369
OPRK13061.558 (0.975–2.490)0.064
OAS13060.915 (0.576–1.453)0.706
BIRC53061.046 (0.658–1.662)0.849
BLNK3060.706 (0.442–1.127)0.144
NCR23061.076 (0.677–1.709)0.757
GZMB3060.803 (0.505–1.277)0.354
MMP93061.144 (0.718–1.821)0.572
BMP73060.675 (0.420–1.083)0.103
IL21R3060.629 (0.394–1.003)0.052
LHB3061.005 (0.633–1.596)0.984
AMH3060.759 (0.477–1.207)0.244
TFR23060.694 (0.435–1.105)0.124
IL23A3060.829 (0.522–1.317)0.427
VDR3061.328 (0.828–2.129)0.239
IL263061.013 (0.638–1.609)0.956
IFNG3060.795 (0.500–1.265)0.333
PTPN63060.721 (0.451–1.150)0.170
ULBP13061.156 (0.722–1.853)0.545
NR2E13061.135 (0.715–1.804)0.591
IL12B3060.550 (0.344–0.880)
HRG3061.002 (0.631–1.593)0.993
CSPG53060.977 (0.615–1.551)0.921
IL1A3061.679 (1.048–2.692)
ZAP703060.458 (0.284–0.740)
STAT13060.831 (0.523–1.320)0.433
IL1RL23061.006 (0.629–1.608)0.982
PROC3060.762 (0.478–1.215)0.253
SDC13061.537 (0.956–2.472)0.076
BMP8B3060.979 (0.616–1.556)0.929
ARTN3060.871 (0.547–1.386)0.560
FASLG3060.813 (0.512–1.292)0.382
SPP13061.686 (1.046–2.719)
TNFSF12–TNFSF133061.284 (0.806–2.045)0.293
TNFSF103060.816 (0.513–1.297)0.389
PLAU3061.417 (0.889–2.259)0.143
ACVR1C3061.712 (1.062–2.759)
PI33061.155 (0.727–1.835)0.542
IL9R3060.674 (0.422–1.079)0.100
IL373061.044 (0.656–1.660)0.856
TNFSF93061.150 (0.723–1.830)0.555
CD703060.732 (0.459–1.166)0.189
SLURP13060.900 (0.566–1.430)0.654
EDN23060.912 (0.572–1.454)0.699
ADM23060.771 (0.485–1.227)0.273
RAC23060.946 (0.596–1.503)0.815
APOBEC3A3060.665 (0.417–1.061)0.087
IRF53060.785 (0.493–1.250)0.307
ULBP23061.840 (1.127–3.004)
ULBP33061.234 (0.775–1.964)0.376
CCL253060.590 (0.367–0.950)
IDO13060.776 (0.488–1.233)0.283
CHIT13060.514 (0.321–0.823)
SPINK53060.831 (0.521–1.327)0.439
VAV33060.707 (0.444–1.125)0.143
GRP3060.943 (0.594–1.498)0.805
IL2RA3060.859 (0.540–1.365)0.520
OASL3060.779 (0.490–1.239)0.292
IL103061.008 (0.635–1.601)0.973
IL36G3061.107 (0.696–1.762)0.667
IL1RN3061.110 (0.695–1.772)0.662
IL36A3060.870 (0.546–1.386)0.559
IL36RN3061.197 (0.752–1.905)0.447
IL36B3060.874 (0.550–1.389)0.570
PAK63060.940 (0.591–1.496)0.795
DUOX13060.439 (0.270–0.712)
CXCL93060.578 (0.362–0.924)
DUOX23060.831 (0.522–1.321)0.433
CBLC3060.915 (0.574–1.461)0.711
IL22RA13061.055 (0.664–1.675)0.822
SYTL13060.912 (0.574–1.449)0.696
S100A83061.081 (0.680–1.718)0.741
S100A73061.144 (0.720–1.817)0.570
UCN23061.124 (0.707–1.788)0.620
ADM3061.570 (0.976–2.524)0.063
IL183060.904 (0.568–1.440)0.672
RAET1L3061.038 (0.652–1.652)0.875
CXCL133060.788 (0.495–1.254)0.314
MX13060.977 (0.615–1.553)0.922
CD1A3060.539 (0.334–0.868)
PGLYRP33060.760 (0.478–1.210)0.248
AGRP3060.667 (0.419–1.062)0.088
FGF113061.806 (1.111–2.936)
SSTR53060.623 (0.390–0.996)
FGF193061.990 (1.224–3.235)
S100A113060.836 (0.526–1.328)0.448
PGLYRP43060.892 (0.562–1.417)0.630
S100A93061.042 (0.656–1.656)0.861
S100A123061.102 (0.692–1.753)0.683
TGFA3061.627 (1.011–2.617)
ICOS3060.741 (0.466–1.178)0.205
CAMP3060.590 (0.368–0.945)
F2RL13061.155 (0.724–1.842)0.545
CSF23061.777 (1.102–2.865)
IL22RA23060.682 (0.429–1.086)0.107
IL31RA3061.132 (0.711–1.803)0.601
RAET1E3061.206 (0.756–1.924)0.431
SYK3060.823 (0.517–1.311)0.412
RNASE73060.921 (0.580–1.462)0.727
HTR3A3060.534 (0.331–0.862)
CHP23060.974 (0.613–1.547)0.911
NOD23061.081 (0.680–1.717)0.743
TAP13060.956 (0.602–1.520)0.851
CXCL103060.736 (0.463–1.171)0.196
CXCL113060.980 (0.617–1.558)0.933
RNASE23061.115 (0.701–1.773)0.647
RAC33060.863 (0.543–1.370)0.532
NRG43061.536 (0.959–2.462)0.074
FABP63061.060 (0.668–1.684)0.804
APLN3061.871 (1.156–3.030)
RASGRP13060.683 (0.428–1.090)0.110
HSPA63061.140 (0.717–1.811)0.580
OLR13061.021 (0.642–1.624)0.929
IL20RB3060.834 (0.524–1.328)0.445
BDNF3061.214 (0.764–1.930)0.411
UMODL13060.451 (0.278–0.731)
CCR83060.875 (0.551–1.389)0.571
EPGN3061.225 (0.770–1.948)0.392
GALR23060.638 (0.397–1.023)0.062
MX23060.843 (0.530–1.341)0.472
CCR33061.349 (0.843–2.158)0.212
S100A7A3061.193 (0.749–1.899)0.458
BPIFC3060.916 (0.576–1.457)0.71
GAST3061.031 (0.649–1.637)0.898
IFNE3061.070 (0.672–1.701)0.776
SEMA4B3061.147 (0.720–1.826)0.563
IFNLR13061.243 (0.780–1.979)0.36
IRF73060.810 (0.510–1.288)0.374
ISG153060.856 (0.539–1.361)0.512
S100A163060.992 (0.625–1.577)0.974
KIR2DL43060.760 (0.477–1.210)0.247
CLDN43060.868 (0.546–1.380)0.551
S100A143061.046 (0.658–1.662)0.85
CXCL173060.764 (0.481–1.214)0.254
IL1RAP3061.288 (0.805–2.058)0.291
SEMA4A3060.734 (0.461–1.167)0.191
CGB73061.091 (0.686–1.736)0.712
S100A23061.271 (0.798–2.025)0.313
FABP123061.107 (0.694–1.766)0.668
RAET1G3061.513 (0.947–2.417)0.083
FCGR3A3060.692 (0.435–1.100)0.119
TRGV43060.661 (0.414–1.057)0.084
TRBV5-53060.818 (0.515–1.300)0.395
TRAV63060.929 (0.585–1.476)0.756
TRAV13-13060.739 (0.465–1.174)0.2
TRAV13-23060.707 (0.444–1.125)0.144
TRAV243060.607 (0.379–0.973)
TRAV26-13060.528 (0.329–0.846)
CGB83061.343 (0.843–2.140)0.214
CSH23060.861 (0.542–1.366)0.524
KLRK13060.559 (0.347–0.901)
LTB4R3060.746 (0.468–1.189)0.218
LTB4R23060.854 (0.536–1.360)0.505
GCGR3061.022 (0.641–1.628)0.928
TNFRSF253060.720 (0.452–1.148)0.168
IFI303060.535 (0.333–0.860)
NTF43061.334 (0.837–2.125)0.225
LTA3060.790 (0.497–1.256)0.319
TNF3061.491 (0.936–2.376)0.093
HLA-DQA23060.672 (0.422–1.071)0.094
CNTF3061.558 (0.972–2.497)0.065
INSL33060.622 (0.389–0.994)
TUBB33061.928 (1.198–3.101)
MMP123061.434 (0.895–2.296)0.134
IKBKE3061.014 (0.638–1.609)0.955
CCL183060.826 (0.520–1.312)0.418
CD79B3060.502 (0.310–0.812)
SEMA3G3061.074 (0.676–1.708)0.763
FYN3060.873 (0.547–1.394)0.571
IGF13060.531 (0.329–0.856)
HGF3061.034 (0.651–1.643)0.888
VIM3061.001 (0.630–1.589)0.997
FLT43060.979 (0.615–1.558)0.928
PTGER33061.013 (0.638–1.609)0.956
CALCRL3061.460 (0.913–2.334)0.114
TIE13060.903 (0.567–1.438)0.668
TGFBR33060.925 (0.582–1.469)0.741
FGF103060.883 (0.555–1.405)0.6
FGFR13060.904 (0.569–1.435)0.669
PGR3060.649 (0.405–1.040)0.072
LTBP43061.040 (0.654–1.656)0.867
THPO3061.112 (0.700–1.767)0.653
ESR13060.990 (0.623–1.572)0.964
CMA13060.743 (0.467–1.182)0.21
SLC22A173061.352 (0.849–2.151)0.204
SERPIND13061.000 (0.630–1.590)0.998
CTSG3060.853 (0.536–1.357)0.501
NFATC43061.019 (0.642–1.618)0.936
ANGPT43061.165 (0.728–1.866)0.525
BPI3060.902 (0.568–1.433)0.663
FLT13061.339 (0.840–2.135)0.22
PDGFRL3060.773 (0.486–1.230)0.277
VIPR23060.811 (0.509–1.292)0.379
OGN3060.702 (0.441–1.118)0.136
CXCL123060.887 (0.558–1.409)0.611
ICAM23060.643 (0.400–1.035)0.069
CD813060.967 (0.606–1.543)0.889
BACH23060.697 (0.439–1.107)0.126
PRLR3061.105 (0.695–1.758)0.673
LIFR3060.983 (0.619–1.561)0.941
PDGFRB3060.851 (0.534–1.354)0.496
TACR13060.878 (0.551–1.399)0.585
ANGPTL13061.071 (0.674–1.701)0.772
LEPR3061.674 (1.040–2.695)
AKT33060.917 (0.577–1.456)0.713
NRP23060.882 (0.555–1.400)0.593
CCN23060.952 (0.600–1.513)0.837
NR4A33060.657 (0.411–1.050)0.079
TEK3060.914 (0.575–1.455)0.706
FABP33061.225 (0.770–1.948)0.391
PTGFR3060.936 (0.588–1.489)0.779
NR4A13061.061 (0.668–1.686)0.802
NDP3061.331 (0.834–2.124)0.231
PTGER23060.841 (0.529–1.336)0.463
THRA3060.979 (0.616–1.555)0.928
MASP13060.861 (0.540–1.372)0.528
IL17B3060.834 (0.525–1.326)0.444
KDR3061.025 (0.644–1.632)0.917
MCHR13061.570 (0.977–2.524)0.063
DLL43061.691 (1.056–2.708)
FGF133060.784 (0.492–1.250)0.307
EPO3060.711 (0.446–1.134)0.152
NGF3061.243 (0.780–1.979)0.36
PDGFRA3060.856 (0.538–1.362)0.512
STAB23060.802 (0.504–1.276)0.351
EDNRB3060.833 (0.521–1.331)0.444
ANGPTL23061.031 (0.649–1.639)0.896
PI153061.331 (0.837–2.118)0.227
THBS13061.415 (0.885–2.261)0.147
FGF23061.082 (0.681–1.718)0.739
RBP53060.967 (0.609–1.536)0.888
ACVRL13061.021 (0.642–1.623)0.929
FGF73060.748 (0.468–1.196)0.225
CCN13060.997 (0.628–1.583)0.989
RXRG3060.856 (0.539–1.360)0.51
LEFTY23060.745 (0.466–1.192)0.22
IL17RD3060.876 (0.552–1.392)0.576
AGTR13060.910 (0.572–1.446)0.689
SLIT23060.746 (0.468–1.190)0.218
PDGFC3061.768 (1.100–2.842)
VIP3061.104 (0.695–1.754)0.675
CTF13060.931 (0.586–1.479)0.761
EDNRA3061.114 (0.701–1.772)0.647
BMP63061.131 (0.712–1.797)0.602
ANGPT13060.946 (0.595–1.503)0.813
PRKCA3061.676 (1.036–2.712)
COLEC123060.916 (0.575–1.459)0.71
CSRP13061.417 (0.888–2.261)0.144
ZYX3061.437 (0.899–2.297)0.13
PTH1R3061.030 (0.648–1.635)0.902
TGFBR23061.310 (0.821–2.091)0.257
VEGFD3060.660 (0.411–1.058)0.084
CMTM53060.802 (0.504–1.275)0.35
AVPR1A3060.886 (0.557–1.410)0.61
ILK3061.559 (0.973–2.499)0.065
AR3060.681 (0.425–1.091)0.11
IL133060.746 (0.469–1.186)0.215
NPR13060.747 (0.469–1.188)0.218
SDC23061.219 (0.767–1.938)0.403
TRH3061.044 (0.656–1.661)0.855
PDGFD3060.925 (0.581–1.472)0.742
S1PR13060.911 (0.572–1.452)0.696
ANGPTL73060.819 (0.514–1.306)0.403
IL17D3061.222 (0.766–1.949)0.4
DES3060.582 (0.361–0.939)
NR2F13060.759 (0.477–1.206)0.243
A2M3060.646 (0.403–1.036)0.07
GREM23061.085 (0.683–1.724)0.73
TAFA13060.670 (0.419–1.071)0.094
GDF33061.008 (0.633–1.604)0.974
NR2F23060.637 (0.397–1.021)0.061
LCN103060.746 (0.469–1.186)0.215
UTS2B3060.777 (0.489–1.235)0.286
APOD3060.533 (0.332–0.857)
ANXA63060.892 (0.561–1.418)0.629
ELANE3060.978 (0.615–1.555)0.925
ANXA63060.892 (0.561–1.418)0.629
ELANE3060.978 (0.615–1.555)0.925
TPM23061.198 (0.753–1.905)0.445
ACKR13060.629 (0.393–1.007)0.054
TAFA53060.914 (0.575–1.453)0.705
TNFSF123061.007 (0.633–1.604)0.975
LCN63060.635 (0.398–1.014)0.057
S1PR23060.577 (0.358–0.931)
CCL233060.660 (0.413–1.053)0.081
CCL163061.138 (0.716–1.810)0.584
CCL143060.930 (0.586–1.477)0.759
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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750