Prognostic-Related Biomarkers in Pancreatic Ductal Adenocarcinoma Correlating with Immune Infiltrates Based on Proteomics

11 March 2023 : Database Analysis

Yan-qi Kou^1ACEF, Yu-ping Yang^1BCE, Zhao-jie Pan^2E, Shen-shen Du^1BC, Wei-nan Yuan^1BC, Kun He^1E, Biao Nie^1A*

DOI: 10.12659/MSM.938785

Med Sci Monit 2023; 29:e938785

Background Material and Methods Results Discussion Conclusions References

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Table 2 Univariate and multivariate analysis of OS in patients with PDAC.

Characteristics	Total (N)	Univariate analysis		Multivariate analysis

		Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)	P value

Gender
Male vs Female	125	1.211 (0.780–1.880)	0.393

Tumor grade
G1–2 vs G3–4	125	1.526 (0.867–2.687)	0.143

Tumor stage
Stage I–II vs stage III–IV	125	1.790 (1.143–2.801)		1.699 (1.066–2.709)

Age (years)
<65 vs ≥65	125	1.118 (0.722–1.732)	0.616

PLG expression
High vs Low	125	1.720 (1.055–2.805)		1.952 (1.134–3.360)

COPS5 expression
High vs Low	125	2.172 (1.345–3.507)		1.904 (1.141–3.177)

EPB42 expression
High vs Low	125	1.712 (1.096–2.676)		1.816 (0.731–4.510)	0.199

FYN expression
High vs Low	125	0.668 (0.423–1.057)		0.537 (0.322–0.896)

ITGB3 expression
High vs Low	125	1.851 (1.187–2.886)		2.044 (1.182–3.533)

SLC4A1 expression
High vs Low	125	1.792 (1.020–3.149)		1.451 (0.697–3.019)	0.319

IRF3 expression
High vs Low	125	0.420 (0.251–0.705)		0.500 (0.281–0.887)

SPTA1 expression
High vs Low	125	1.513 (0.978–2.343)	0.063	0.379 (0.159–0.900)
The parameters from our cohort, including gender, tumor grade, tumor stage, age, and PLG, COPS5, EPB42, FYN, ITGB3, SLC4A1, IRF3, SPTA1 expression in PDAC were used for univariate Cox regression analyses and significant factors (P

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